Author

I. Franzoni

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Research Focus:protein structure prediction· 2 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

M. K. Mann· 3 shared M. Schapira· 3 shared C. H. Arrowsmith· 2 shared M. Lautens· 2 shared R. Ferreira de Freitas· 2 shared R. J. Harding· 2 shared V. Santhakumar· 2 shared A. Scheremetjew· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersPharmacology & Toxicology

M. K. Mann

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3 papers

Recent·Most cited

Discovery and characterization of a chemical probe targeting the zinc-finger ubiquitin-binding domain of HDAC6

R. J. Harding, I. Franzoni, M. K. Mann, M. Szewczyk, B. Mirabi, D. D. Owens, S. Ackloo, A. Scheremetjew, K. A. Juarez-Ornelas, R. Sanichar, R. J. Baker, C. Dank, P. J. Brown, D. Barsyte-Lovejoy, V. Santhakumar, , C. H. Arrowsmith

The paper identifies and characterizes a chemical probe, SGC-UBD253, that targets the HDAC6 UBD with selectivity, and a less active derivative as a negative control.

bioRxiv · Feb 21, 2023Pharmacology & Toxicology

Discovery of small molecule antagonists of the USP5 zinc finger ubiquitin-binding domain

M. K. Mann, I. Franzoni, R. Ferreira de Freitas, W. Tempel, S. Houliston, C. H. Arrowsmith, R. J. Harding, M. Schapira

The paper identifies small molecule antagonists targeting the USP5 ZnF-UBD, providing a framework for developing chemical probes to study its role in ubiquitin signaling.

bioRxiv · Jun 22, 2019Pharmacology & Toxicology

Identification and Structure-Activity Relationship of HDAC6 Zinc-finger Ubiquitin Binding Domain Inhibitors

R. Ferreira de Freitas, R. Harding, I. Franzoni, M. Ravichandran, M. K. Mann, H. Ouyang, M. Lautens, V. Santhakumar, C. Arrowsmith, M. Schapira

The paper identifies HDAC6 ZnF-UBD inhibitors and describes their structure-activity relationships, revealing key binding features and potential for further optimization.

bioRxiv · Feb 20, 2018Biophysics