Author

A. Schiepers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Organism:non-human primate· 1

Frequent Co-Authors

G. D. Victora· 4 shared L. Mesin· 3 shared A. J. Greaney· 2 shared H. Muramatsu· 2 shared N. Pardi· 2 shared A. A. Cohen· 1 shared A. Hobbs· 1 shared A. I. Ramsingh· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersImmunology

G. D. Victora

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4 papers

Recent·Most cited

Mosaic sarbecovirus nanoparticles elicit cross-reactive responses in pre-vaccinated animals

A. A. Cohen, J. R. Keeffe, A. Schiepers, S. E. Dross, A. J. Greaney, A. V. Rorick, H. Gao, P. N. P. Gnanapragasam, C. Fan, A. P. West, A. I. Ramsingh, J. H. Erasmus, J. D. Pata, H. Muramatsu, N. Pardi, , P. J. Bjorkman

The paper shows mosaic-8b nanoparticles induce broader cross-reactive antibodies than homotypic ones, even in pre-vaccinated animals, suggesting potential for improved vaccine design against emerging sarbecoviruses.

bioRxiv · Feb 8, 2024Immunology

Opposing effects of pre-existing antibody and memory T cell help on the dynamics of recall germinal centers

A. Schiepers, M. F. L. van 't Wout, A. Hobbs, L. Mesin, G. D. Victora

This study investigates how pre-existing antibodies and memory T cell help influence the dynamics of recall germinal centers, showing that pre-existing antibodies suppress antigen binding while memory T cells enable B cells to access GCs despite low antigen binding.

bioRxiv · Dec 15, 2023Immunology

Molecular fate-mapping of serum antibodies reveals the effects of antigenic imprinting on repeated immunization

A. Schiepers, M. F. van 't Wout, A. J. Greaney, T. Zang, H. Muramatsu, P. J. Lin, Y. K. Tam, L. Mesin, T. N. Starr, P. D. Bieniasz, N. Pardi, J. D. Bloom, G. D. Victora

This study uses molecular fate-mapping to show that repeated immunization preferentially reuses initial B cell clones over recruiting new ones, with imprinting effects decreasing as antigenic distance increases.

bioRxiv · Aug 29, 2022 · PreprintImmunology

Sustained antibody response to ZIKV infection induced by NS1 protein is accompanied by the progressive appearance of autoreactive antibodies and cross-reactive B cell clones.

C. B. Cavazzoni, V. B. Bozza, L. Tostes, B. Maia, L. Mesin, A. Schiepers, J. Ersching, R. L. Neris, J. N. Conde, D. R. Coleho, L. Conde, H. A. Paula-Neto, T. M. Lima, R. G. F. Alvim, L. R. Castilho, , A. M. Vale

The paper investigates the humoral immune response to Zika virus NS1, showing its immunodominance and association with autoreactive and cross-reactive B cell clones.

bioRxiv · Dec 24, 2020Immunology