L. Mesin

Opposing effects of pre-existing antibody and memory T cell help on the dynamics of recall germinal centers

This study investigates how pre-existing antibodies and memory T cell help influence the dynamics of recall germinal centers, showing that pre-existing antibodies suppress antigen binding while memory T cells enable B cells to access GCs despite low antigen binding.

Proximity-dependent labeling identifies dendritic cells that drive the tumor-specific CD4+ T cell response

The paper identifies dendritic cells that present antigens to CD4+ T cells in tumor-draining lymph nodes and the tumor microenvironment using LIPSTIC-based single-cell transcriptomics.

Molecular fate-mapping of serum antibodies reveals the effects of antigenic imprinting on repeated immunization

This study uses molecular fate-mapping to show that repeated immunization preferentially reuses initial B cell clones over recruiting new ones, with imprinting effects decreasing as antigenic distance increases.

Sustained antibody response to ZIKV infection induced by NS1 protein is accompanied by the progressive appearance of autoreactive antibodies and cross-reactive B cell clones.

The paper investigates the humoral immune response to Zika virus NS1, showing its immunodominance and association with autoreactive and cross-reactive B cell clones.

Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells

This study identifies cyclin D3 as essential for inertial cell cycling in dark zone germinal center B cells, enabling clonal expansion and linking it to potential lymphoproliferative disorders.

T cell receptor is required for differentiation but not maintenance of intestinal intraepithelial lymphocytes

Compartmentalized lymph node drainage dictates intestinal adaptive immune responses

This study shows that mesenteric lymph nodes (mLNs) along the intestine are functionally distinct, with proximal mLNs promoting tolerance and distal mLNs driving inflammation, and demonstrates how disruptions in this compartmentalization affect immune responses.

One-step generation of monoclonal B cell receptor mice capable of class switch recombination and somatic hypermutation

This paper describes a method to generate monoclonal B cell receptor mice capable of somatic hypermutation and class switch recombination using CRISPR/Cas9.