Y. K. Tam

This paper develops VCAM-targeted lipid nanoparticles to enhance drug delivery to the blood-brain barrier in acute ischemic stroke, reducing infarct volume and mortality.

This study shows the microbiome affects nucleic acid vaccine responses differently depending on the vaccine type, enhancing mRNA-LNP responses but suppressing DNA-prime/DNA-protein-boost responses.

A T cell vaccine based on conserved epitopes protects HLA transgenic mice from SARS-CoV-2 Beta variant mortality without inducing neutralizing antibodies.

This study uses molecular fate-mapping to show that repeated immunization preferentially reuses initial B cell clones over recruiting new ones, with imprinting effects decreasing as antigenic distance increases.

This study uses mRNA lipid nanoparticles to deliver an active STING mutant to treat STING-deficient cancers, enhancing immune response and inducing cancer cell death.

This paper demonstrates a modular lipid nanoparticle platform for co-delivering siRNA and lipophilic prodrugs to achieve additive anti-cancer effects in vitro.