Opposing effects of pre-existing antibody and memory T cell help on the dynamics of recall germinal centers
A. Schiepers, M. F. L. van 't Wout, A. Hobbs, L. Mesin, G. D. Victora
This study investigates how pre-existing antibodies and memory T cell help influence the dynamics of recall germinal centers, showing that pre-existing antibodies suppress antigen binding while memory T cells enable B cells to access GCs despite low antigen binding.
bioRxiv · Dec 15, 2023Immunology