Determining the specificity of Cascade binding, interference, and primed adaptation in vivo in the Escherichia coli type I-E CRISPR-Cas system
L. Cooper, A. Stringer, J. Wade
This study investigates Cascade binding, interference, and primed adaptation specificity in E. coli type I-E CRISPR-Cas system in vivo, showing low binding specificity but high specificity for interference and adaptation.
bioRxiv · Mar 16, 2018Microbiology