L. Cooper

Revisiting the lineages of the Cohanim using data from next-generation sequencing

This study uses whole-Y sequencing to identify and date Cohen lineages, revealing nine major branches and their geographic dispersal across the Jewish Diaspora.

Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity

The paper identifies transcriptional modules and cytokine signaling pathways that drive functional heterogeneity in T follicular helper cells across different infections.

Designer DNA NanoGripper

The paper designs, synthesizes, and characterizes a DNA nanorobot, NanoGripper, capable of capturing viral particles and functioning as a biosensor for SARS-CoV-2 detection in human saliva.

Imetelstat-Mediated Alterations in Fatty Acid Metabolism To Induce Ferroptosis As Therapeutic Strategy for Acute Myeloid Leukemia

This study identifies ferroptosis as a mechanism by which imetelstat induces therapeutic effects in AML, showing that targeting fatty acid metabolism enhances its efficacy.

Type I interferon dynamics determines memory B cell epigenetic identity in chronic viral infection

The paper identifies type I interferon dynamics as a key factor shaping memory B cell development during chronic viral infection and shows that early IFNAR-1 blockade can reverse chromatin changes.

Oncogenic drivers dictate immune control of acute myeloid leukemia.

This study shows that specific AML oncogenes influence immune responses and escape mechanisms, with NrasG12D promoting anti-leukemia immunity that can be counteracted by Myc.

An engineered ACE2 decoy receptor can be administered by inhalation and potently targets the BA.1 and BA.2 omicron variants of SARS-CoV-2

COVID-19 vaccine booster induces a strong CD8+ T cell response against Omicron variant epitopes in HLA-A*02:01+ individuals

Expression of CD49f defines subsets of human regulatory T cells with divergent transcriptional landscape and function that correlate with ulcerative colitis disease activity

The paper identifies CD49f-expressing subsets of human regulatory T cells with distinct transcriptional profiles and functions linked to ulcerative colitis disease activity.

Potent, Novel SARS-CoV-2 PLpro Inhibitors Block Viral Replication in Monkey and Human Cell Cultures

This study identifies potent non-covalent SARS-CoV-2 PLpro inhibitors that block viral replication in human and monkey cell cultures with low nanomolar potency.

Novel ACE2-IgG1 fusions with improved in vitro and in vivo activity against SARS-CoV2

This paper develops a modified ACE2-IgG1 fusion protein with enhanced in vivo activity against SARS-CoV2, showing improved lung bioavailability and viral neutralization.

Low coverage genomic data resolve the population divergence and gene flow history of an Australian rain forest fig wasp

The paper uses low coverage genomic data to infer the divergence and gene flow history of an Australian rain forest fig wasp, finding strong support for an admixture model.

A glycosaminoglycan extract from Portunus pelagicus inhibits BACE1, the β secretase implicated in Alzheimer’s disease

This study identifies a marine-derived glycosaminoglycan extract from Portunus pelagicus that inhibits BACE1 with reduced anticoagulant activity compared to mammalian heparin.

Determining the specificity of Cascade binding, interference, and primed adaptation in vivo in the Escherichia coli type I-E CRISPR-Cas system

This study investigates Cascade binding, interference, and primed adaptation specificity in E. coli type I-E CRISPR-Cas system in vivo, showing low binding specificity but high specificity for interference and adaptation.