R. Johnson

Rhizaria in the oligotrophic ocean exhibit clear temporal and vertical variability

This study quantifies Rhizaria abundance and vertical distribution over a year in the Sargasso Sea, showing taxonomic partitioning and environmental influences.

The global fish and invertebrate abundance value of mangroves

This study estimates the global abundance of 37 commercially important fish and invertebrates in mangroves, finding high densities in specific regions and highlighting mangroves' critical role in fisheries.

Viral Syncytia Evolve to Resist Interferon

This study shows that SARS-CoV-2 syncytia reduce interferon and antibody effectiveness, explaining the evolution of fusogenic viral variants.

Together, Neuropilin 1 and Neuropilin 2 direct α5 integrin trafficking through GTPase-activating-protein p120RasGAP in endothelial cells to promote fibronectin fibrillogenesis

This study identifies NRP1 and NRP2's role in regulating α5 integrin trafficking via p120RasGAP in endothelial cells, promoting fibronectin fibrillogenesis.

Microeukaryote metabolism across the western North Atlantic Ocean revealed through autonomous underwater profiling

The paper uses metatranscriptomic and metaproteomic analysis of plankton biomass collected across a 1,050 km transect in the western North Atlantic Ocean to reveal shifts in microeukaryote community composition and metabolic function across depth and environmental gradients.

Connecting Thiamine Availability to the Microbial Community Composition in Chinook Salmon Spawning Habitats of the Sacramento River Basin

The paper investigates thiamine and its metabolites (dTRCs) in Sacramento River spawning habitats, linking microbial communities to thiamine availability for Chinook salmon.

Atypical Chemokine Receptor 1 (Ackr1)-deficient Mice Resist Lethal SARS-CoV-2 Challenge

This study shows that Ackr1-deficient mice have lower mortality from SARS-CoV-2 infection, suggesting ACKR1 may contribute to COVID-19 immunopathology and could be a drug target.

MBNL1 regulates programmed postnatal switching between regenerative and differentiated cardiac states.

This study identifies MBNL1 as a regulator of cardiac cell state transitions, showing it controls RNA stability to switch between regenerative and differentiated states.

Live-attenuated pediatric parainfluenza vaccine expressing 6P-stabilized SARS-CoV-2 spike protein is protective against SARS-CoV-2 variants in hamsters

This study compares two live-attenuated vaccines in hamsters, showing that B/HPIV3/S-6P induces stronger immune responses and better protection against SARS-CoV-2 variants than B/HPIV3/S-2P.

Zinc and laboratory emerge date impact honey bee gut microbiota and survival

This study examines the effects of zinc exposure and emerge date on honey bee survival and gut microbiota, finding minimal survival impact but significant microbiota changes.

Hepatocyte Growth Factor and β1-integrin signalling axis drives tunneling nanotube formation in A549 lung adenocarcinoma cells

This study identifies a novel HGF/c-Met and β1-integrin signalling axis that drives tunneling nanotube formation in A549 lung adenocarcinoma cells, suggesting a target for multi-drug therapy in NSCLC.

Oxygen levels at the time of activation determine T cell persistence and immunotherapeutic efficacy

The paper shows that low oxygen levels during T cell activation enhance antitumour cytotoxicity, even when subsequent culture is under high oxygen.

Diet Induced Obesity and Diabetes Enhance Mortality and Reduces Vaccine Efficacy for SARS-CoV-2

This study shows that obesity and diabetes increase SARS-CoV-2 mortality and reduce vaccine efficacy in mice, with neutrophil depletion improving outcomes.

N-linked glycosylation increases horse radish peroxidase rigidity leading to enhanced activity and stability.

This study shows glycosylation increases the rigidity of horseradish peroxidase, enhancing its activity and stability through structural changes.

Is evolutionary conservation a useful predictor for cancer long noncoding RNAs? Insights from the Cancer lncRNA Census 3

The paper examines the relationship between evolutionary conservation and the discovery year of cancer lncRNAs, finding an inverse correlation that suggests potential sampling bias and questions the utility of evolutionary metrics in prioritizing cancer lncRNAs.

Convalescence from prototype SARS-CoV-2 protects Syrian hamsters from disease caused by the Omicron variant

This study shows that prior infection with a prototype SARS-CoV-2 strain protects Syrian hamsters from Omicron-induced disease.

Engraftment, fate, and function of HoxB8-conditional neutrophil progenitors in the unconditioned murine host

This study shows HoxB8-conditional neutrophil progenitors can engraft in naive mice without niche conditioning, generate mature neutrophils, and respond to inflammation via known recruitment mechanisms.

Lactate regulation of activation in CD8+ T cells

This study shows lactate can displace glucose as a carbon source for activated CD8+ T cells and alters their transcriptome, affecting effector differentiation markers.

Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge

This study shows that intravenous BCG vaccination protects mice from lethal SARS-CoV-2 infection by altering pulmonary myeloid cell function and reducing immunopathology.

Pyrimidine biosynthesis inhibitors synergize with nucleoside analogs to block SARS-CoV-2 infection

The paper screens 18,000 drugs for antiviral activity against SARS-CoV-2, identifies synergistic combinations of pyrimidine biosynthesis inhibitors and nucleoside analogs, and validates their efficacy in vitro and in vivo.

Immunogenicity and In vivo protection of a variant nanoparticle vaccine that confers broad protection against emerging SARS-CoV-2 variants

This study evaluates a nanoparticle vaccine against SARS-CoV-2 variants, showing it induces strong immune responses and protection in mice and baboons against multiple variants.

Identification of Actin Filament Interactors in Giardia lamblia

This study identifies 46 putative actin filament interactors in Giardia lamblia, including proteins localized to the ventral disc, suggesting a role for GlActin in host attachment.

Structure guided engineering of a cold active esterase expands substrate range though a stabilisation mutation that allows access to a buried water chamber

The paper engineers a cold-active esterase to expand its substrate range by stabilizing a structural mutation that allows access to a buried water chamber.

The innate immunity protein C1QBP functions as a negative regulator of circulative transmission of Potato leafroll virus by aphids

This study identifies C1QBP as a negative regulator of Potato leafroll virus transmission by aphids using AP-MS and functional assays.

Cancer LncRNA Census 2 (CLC2): an enhanced resource reveals clinical features of cancer lncRNAs

CLC2 expands the catalog of cancer lncRNAs to 492, including 95 novel ones, and links them to clinical and genomic features for precision medicine.

The effect of proximity on the function and energy transfer capability of fluorescent protein pairs

This study shows that dimerization of fluorescent protein pairs alters their fluorescent properties and FRET efficiency, challenging assumptions about FP-based proximity sensing.

Palmitate-induced toxicity is associated with impaired mitochondrial respiration and accelerated oxidative stress in cultured cardiomyocytes: the critical role of Coenzyme Q9/10

This study investigates how palmitate affects mitochondrial respiration, oxidative stress, and CoQ levels in cardiomyocytes, showing that CoQ response is critical for mitochondrial protection.

ADAMTS-1 and Syndecan-4 intersect in the regulation of cell migration and angiogenesis

This study shows ADAMTS-1 and syndecan-4 regulate cell migration and angiogenesis through MMP-9 and fibulin-1 interactions.

Beach environmental DNA fills gaps in photographic biomonitoring to track spatiotemporal community turnover across 82 phyla

This paper compares eDNA metabarcoding and photographic observations to assess biodiversity and community turnover across 82 phyla, finding eDNA captures seasonal changes and links protected areas to better-sampled sites.

Lactate potentiates differentiation and expansion of cytotoxic T cells

This study shows that lactate enhances the anti-tumour activity of cytotoxic T cells by increasing their proliferation and cytotoxicity during exercise.