J. Wade

The small mycobacterial ribosomal protein, bS22, modulates aminoglycoside accessibility to its 16S rRNA helix-44 binding site

This study shows that the mycobacterial ribosomal protein bS22 modulates aminoglycoside binding to the 16S rRNA helix-44 site, influencing antibiotic resistance.

Discovery of a broadly-neutralizing human antibody that can rescue mice challenged with neurotoxin-rich snake venoms

This paper describes the discovery of a broadly-neutralizing human antibody effective against multiple snake venoms, demonstrating its therapeutic potential in mice.

Pervasive Translation in Mycobacterium tuberculosis

This study identifies previously unknown translated ORFs in Mycobacterium tuberculosis using ribosome profiling, revealing pervasive translation of short ORFs that may contribute to evolutionary innovation.

Characterization of Primed Adaptation in the Escherichia coli type I-E CRISPR-Cas System

This study demonstrates that primed adaptation in the E. coli type I-E CRISPR-Cas system is significantly more efficient than naive adaptation, with spacers acquired over large genomic distances.

Dissecting psa locus regulation in Yersinia pestis

This study identifies PsaE's role in regulating psaA in Yersinia pestis, showing its temperature- and pH-dependent expression and binding sites across the genome.

Determining the specificity of Cascade binding, interference, and primed adaptation in vivo in the Escherichia coli type I-E CRISPR-Cas system

This study investigates Cascade binding, interference, and primed adaptation specificity in E. coli type I-E CRISPR-Cas system in vivo, showing low binding specificity but high specificity for interference and adaptation.

Identification of regulatory targets for the bacterial Nus factor complex

The paper identifies regulatory targets of the bacterial Nus factor complex, showing it represses its own gene and regulates other genes through translation inhibition and Rho-dependent termination.