BiochemistrybioRxiv
Extrachromosomal Telomeres Derived from Excessive Strand Displacements
J. Lee, J. Lee, E. J. Sohn…·J. Min
This study identifies the generation mechanism of C-rich single-stranded DNAs and C-circles in ALT cancers using a novel assay, showing their origin from Okazaki fragment processing and CST-PP complex-mediated DNA synthesis.
DOI 10.1073/pnas.2318438121