J. Min

Metabolic Reprogramming by Mutant GNAS Creates an Actionable Dependency in Intraductal Papillary Mucinous Neoplasms of the Pancreas

This study shows that mutant GNAS drives a gastric metaplasia gene signature and glycolytic dependency in IPMNs, offering a therapeutic target.

Population genetics meets ecology: a guide to individual-based simulations in continuous landscapes

This paper provides a guide to implementing individual-based simulations in continuous landscapes, focusing on population dynamics and ecological applications.

Asymmetric Allostery in Estrogen Receptor-α Homodimers Drives Responses to the Ensemble of Estrogens in the Hormonal Milieu

This paper shows that estrogen receptor-α homodimers can function as conformational heterodimers, integrating different ligand signals to produce distinct agonist or antagonist activity profiles.

Designer micro/nano-crumpled MXene multilayer coatings accelerate osteogenesis and regulate macrophage polarization

This study shows that MXene/HAP-coated surfaces with crumpled topography enhance osteogenesis and shift macrophages to an anti-inflammatory M2 phenotype, improving implant integration.

Structural insights into specific recognition of PTENα/β-NTE by WDR5 in cancer progression

The paper determines the crystal structure of PTEN-NTE bound to WDR5, revealing a specific binding motif that promotes tumor growth and suggests WDR5 inhibitors as potential cancer therapies.

Chemical Tools for the Gid4 Subunit of the Human E3 Ligase C-terminal to LisH (CTLH) Degradation Complex

The paper develops chemical tools and probes for the Gid4 subunit of the human CTLH E3 ligase complex, achieving sub-100 nM binding affinity for further study.

Integrated spatial transcriptomics and lipidomics of precursor lesions of pancreatic cancer identifies enrichment of long chain sulfatide biosynthesis as an early metabolic alteration

Extrachromosomal Telomeres Derived from Excessive Strand Displacements

This study identifies the generation mechanism of C-rich single-stranded DNAs and C-circles in ALT cancers using a novel assay, showing their origin from Okazaki fragment processing and CST-PP complex-mediated DNA synthesis.

Spatial Transcriptomics of Intraductal Papillary Mucinous Neoplasms of The Pancreas Identifies NKX6-2 as a Driver of Gastric Differentiation and Indolent Biological Potential

This study identifies NKX6-2 as a driver of gastric differentiation in IPMNs, linking its expression to indolent biological potential and progression.

The zinc transporter Slc30a1 in macrophages plays a protective role against Salmonella infection

This study shows that Slc30a1 in macrophages protects against Salmonella infection by maintaining zinc homeostasis and reducing oxidative stress.

Stretchable, nano-crumpled MXene multilayers impart long-term antibacterial surface properties

This paper develops a stretchable MXene coating with crumpled nanostructures that provides long-term antibacterial effects and can remove adhered bacteria through dynamic deformation.

Benzidine Induces Proliferation of UMUC3 Bladder Cancer Cells Through Activation of ERK5 Pathway

This study shows benzidine promotes bladder cancer cell proliferation via the ERK5 pathway by increasing cyclin D1 and PCNA while decreasing p21.

Spatial structure alters the site frequency spectrum produced by hitchhiking

This study shows spatial structure changes the site frequency spectrum from hitchhiking, revealing distinct frequency regimes near and far from a selective sweep.

A small-molecule antagonist for the Tudor domain of SMN disrupts the interaction between SMN and RNAP II

This paper identifies a small-molecule antagonist targeting the Tudor domain of SMN, disrupting its interaction with RNAP II and mimicking SMN depletion effects.

Single-dose AAV-based vaccine induces a high level of neutralizing antibodies against SARS-CoV-2 in rhesus macaques

This study shows a single-dose AAV-based vaccine induces long-lasting neutralizing antibodies against multiple SARS-CoV-2 variants in rhesus macaques.

PFKFB3 DEPLETION ACTIVATES β-CELL REPLICATION BY CELL COMPETITIVE CULLING OF COMPROMISED β-CELLS UNDER STRESS

This study shows that PFKFB3 depletion in β-cells under diabetogenic stress increases β-cell replication by removing damaged cells, improving β-cell function and mass.

Pharmacological targeting of a PWWP domain demonstrates cooperative control of NSD2 localization

The paper develops a chemical probe, UNC6934, that targets the PWWP1 domain of NSD2, revealing cooperative control of NSD2 localization through chromatin reader domains.

A human antibody with blocking activity to RBD proteins of multiple SARS-CoV-2 variants including B.1.351 showed potent prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus macaques

Modeling the impact of single-cell stochasticity and size control on the population growth rate in asymmetrically dividing cells

The paper models how single-cell stochasticity and size control affect population growth rates in asymmetrically dividing cells, finding that asymmetric division can enhance growth rates under strong size control.

Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2

This study identifies small-molecule antagonists of the NSD2 PWWP domain that block its interaction with H3K36me2, providing a tool for further investigation of NSD2's role in disease.

Phenotypic and molecular evolution across 10,000 generations in laboratory budding yeast populations

This study tracks phenotypic and molecular evolution in 205 yeast populations over 10,000 generations, revealing patterns of declining adaptability, mutation accumulation, and genetic parallelism.

Dual mechanism estrogen receptor inhibitors

This paper develops dual-mechanism ER inhibitors that use two distinct targeting moieties to suppress ER activity in breast cancer cells and resistance models.

Probing the Plasticity in the Active Site of Protein N-terminal Methyltransferase 1 Using Bisubstrate Analogs

This study examines bisubstrate analog interactions with NTMT1 to understand active site plasticity and identifies a 4-C linker analog as the most potent inhibitor.

Selective Peptidomimetic Inhibitors of NTMT1/2: Rational design, synthesis, characterization, and crystallographic studies

This paper designs and characterizes peptidomimetic inhibitors of NTMT1/2, showing high selectivity and cell-permeable activity.

Structural basis for EPC1-mediated recruitment of MBTD1 into the NuA4/TIP60 acetyltransferase complex

The paper determines the crystal structure of the MBTD1-EPC1 complex, revealing the molecular mechanism of MBTD1 recruitment into the NuA4/TIP60 acetyltransferase complex.

Dynamics of diffusive cell signaling relays

This study shows that diffusive signaling relays enable fast-traveling chemical waves, which create steep gradients for cell communication, and demonstrates their relevance in immune response.

Identification and Characterization of the First Fragment Hits for SETDB1 Tudor Domain

The paper identifies small molecule fragments that bind to the tudor domain of SETDB1 and describes their binding modes and biophysical properties.

A Chemical Probe of CARM1 Alters Epigenetic Plasticity against Breast Cancer Cell Invasion

This study identifies SKI-73 as a CARM1 chemical probe that reduces breast cancer cell invasion by altering epigenetic plasticity, distinct from CARM1 knockout effects.

Plasticity at the DNA recognition site of the MeCP2 mCG-binding domain

This study investigates how MeCP2 recognizes unmethylated 5-CAC/GTG-3 DNA motifs through binding and structural analysis, revealing its adaptability and potential role in transcription activation and Rett syndrome.

Structural insights into SETD3-mediated histidine methylation on β-actin

This study presents two structures of SETD3 bound to β-actin peptides, revealing sequence-specific recognition and methylation mechanism.