Experimenter familiarization is a crucial prerequisite for assessing behavioral outcomes and reduces stress in mice not only under chronic pain conditions
D. Segelcke, S. R. Talbot, R. Palme, C. La Porta, E. M. Pogatzki-Zahn, A. Bleich, A. Tappe-Theodor
This study examines how experimenter familiarization affects pain-related behavior and stress in mice with chronic pain, finding it reduces stress but does not significantly alter pain severity.
bioRxiv · Oct 3, 2022Animal Behavior & Cognition