A. Bleich

Contribution of bacterial and host factors to pathogen "blooming" in a gnotobiotic mouse model for Salmonella enterica serovar Typhimurium-induced enterocolitis

This study investigates how bacterial and host factors contribute to Salmonella 'blooming' in a gnotobiotic mouse model of enterocolitis, showing that inflammation and specific Salmonella traits influence microbial community shifts and pathogen abundance.

Expression-based machine learning models for predicting plant tissue identity

The paper uses Arabidopsis gene expression data to train machine learning models for predicting tissue identity in other flowering plants, finding that gene expression signatures are more predictive than marker genes.

Towards substitution of invasive telemetry: An integrated home cage concept for unobstrusive monitoring of objective physiological parameters in rodents

This paper introduces a smart home cage system for monitoring physiological parameters in rodents without invasive telemetry, demonstrating the extraction of vital signs like heart and respiratory rates.

Robustness of a multivariate composite score when evaluating distress of animal models for gastrointestinal diseases

The paper evaluates distress parameters in animal models of gastrointestinal diseases and introduces RELSA, a composite score that robustly assesses severity across models.

Experimenter familiarization is a crucial prerequisite for assessing behavioral outcomes and reduces stress in mice not only under chronic pain conditions

This study examines how experimenter familiarization affects pain-related behavior and stress in mice with chronic pain, finding it reduces stress but does not significantly alter pain severity.

The gut microbiota promotes liver regeneration through hepatic membrane phospholipid synthesis

This study shows that gut microbiota supports liver regeneration by promoting hepatic phospholipid synthesis, with antibiotic-induced dysbiosis impairing this process.

Diet prevents the expansion of segmented filamentous bacteria and ileo-colonic inflammation in a model of Crohn's disease

This study shows that diet can prevent ileo-colonic inflammation in a Crohn's disease model by reducing segmented filamentous bacteria (SFB) abundance.

Enhanced cultured diversity of the mouse gut microbiota enables custom-made synthetic communities

The paper expands a mouse gut microbiota collection to 212 strains, enabling the creation of custom synthetic communities and improving the Oligo-Mouse Microbiota model.

One score to rule them all: severity assessment in laboratory mice

This paper develops a severity assessment score for laboratory mice using physiological and behavioral data to evaluate postoperative recovery and model-specific severity levels.