Author

I. Schaefer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Evolutionary Biology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Assay:cryo-EM· 1

Frequent Co-Authors

A. Brandt· 2 shared J. Bast· 2 shared M. Maraun· 2 shared S. Scheu· 2 shared T. Schwander· 2 shared A. Tappe-Theodor· 1 shared B. Brankatschk· 1 shared B. Heimburger· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersEvolutionary Biology

A. Brandt

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Author profile →

5 papers

Recent·Most cited

The molecular mechanism and physiological role of silent nociceptor activation

T. A. Nees, N. Wang, P. Adamek, C. Verkest, C. LaPorta, I. Schaefer, J. Virnich, S. Balkaya, V. Prato, C. Morelli, N. Zeitzschel, V. Begay, Y. J. Lee, A. Tappe-Theodor, G. R. Lewin, , S. G. Lechner

This study identifies TMEM100 as a key regulator of silent nociceptor activation during inflammation and shows its role in inducing remote pain hypersensitivity.

bioRxiv · Apr 7, 2022 · PreprintNeuroscience

Nse5/6 inhibits the Smc5/6 ATPase to facilitate DNA substrate selection.

M. Taschner, J. Basquin, B. Steigenberger, I. Schaefer, Y.-M. Soh, C. Basquin, E. Lorentzen, M. Raeschle, R. A. Scheltema, S. Gruber

The paper shows Nse5/6 inhibits Smc5/6 ATPase activity, modulating DNA substrate selection in yeast.

bioRxiv · Feb 9, 2021Biochemistry

Haplotype divergence supports ancient asexuality in the oribatid mite Oppiella nova

A. Brandt, P. Tran Van, C. Bluhm, Y. Anselmetti, Z. Dumas, E. Figuet, C. M. Francois, N. Galtier, B. Heimburger, K. S. Jaron, M. Labedan, M. Maraun, D. J. Parker, M. Robinson-Rechavi, I. Schaefer, , J. Bast

The paper uses genomic and transcriptomic data to show haplotype divergence patterns in asexual and sexual mite species, supporting ancient asexuality in Oppiella nova.

bioRxiv · Dec 7, 2020Evolutionary Biology

Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain

T. Gutmann, I. Schaefer, C. Poojari, B. Brankatschk, I. Vattulainen, M. Strauss, U. Coskun

The paper reports the cryo-EM structure of the insulin receptor ectodomain with four insulin molecules, revealing two binding sites and a T-shaped conformation.

bioRxiv · Jun 21, 2019Biochemistry

Effective purifying selection in ancient asexual oribatid mites

A. Brandt, I. Schaefer, J. Glanz, T. Schwander, M. Maraun, S. Scheu, J. Bast

The paper compares purifying selection effectiveness in asexual and sexual oribatid mite lineages, finding stronger selection in asexuals despite no sex.

bioRxiv · Mar 7, 2017Evolutionary Biology