N. Wang

TLR5 drives metabolic dysfunction-associated steatohepatitis through lipid- and flagellin-induced hepatocyte injury signalling

The paper investigates TLR5's role in MASH and fibrosis using clinical data, single-cell transcriptomics, and in vitro models, finding TLR5 drives hepatocyte injury and fibrosis through flagellin and lipid pathways.

A detailed analysis of 16S rRNA gene sequencing and conventional PCR-based testing for the diagnosis of bacterial pathogens and discovery of novel bacteria

This study compares 16S rRNA gene sequencing and conventional PCR for diagnosing bacterial pathogens in chickens with swollen head syndrome, finding that sequencing is more reliable and can detect novel bacteria.

A transcription factor quintet orchestrating bundle sheath expression in rice

The paper identifies a conserved transcription factor quintet that drives bundle sheath-specific gene expression in rice and shows its functionality in Arabidopsis.

Cas12a/3 crRNAs RNP transformation enables transgene-free multiplex genome editing, long deletions, and inversions in citrus chromosome in the T0 generation

Parallel Analyses by Mass Spectrometry (MS) and Reverse Phase Protein Array (RPPA) Reveal Complementary Proteomic Profiles in Triple-Negative Breast Cancer (TNBC) Patient Tissues and Cell Cultures

The paper compares Mass Spectrometry (MS) and Reverse Phase Protein Array (RPPA) in TNBC samples to assess their performance and identify complementary proteomic profiles.

The genomic and epigenomic dynamics of hemizygous genes across crops with contrasting mating systems

This study examines hemizygous genes in 22 crop genomes, finding higher hemizygosity in clonal lineages and distinct expression and epigenetic features compared to diploid genes.

Asymmetric binding of coactivator SRC1 to FXR-RXR and allosteric communication within the complex

This study reveals the asymmetric binding of SRC1 to FXR-RXR and the allosteric communication within the complex, providing a structural model for understanding FXR function and its disease implications.

SHP-1 interacts with NFκB1 to inhibit its phosphorylation and nuclear translocation to suppress excessive bacterial inflammation

This study shows SHP-1 interacts with NFκB1 to inhibit its phosphorylation and nuclear translocation, thereby suppressing bacterial inflammation in Chinese tongue sole.

Extracellular vesicles-based point-of-care testing for the diagnosis and monitoring of Alzheimer's disease

This paper presents an OECT-based sensor for rapid, sensitive detection of extracellular vesicles in Alzheimer's disease, showing improved sensitivity and reduced detection time.

Spherical Echo-Planar Time-resolved Imaging (sEPTI) for rapid 3D quantitative T2* and Susceptibility imaging

This paper introduces sEPTI, a 3D imaging technique for rapid whole-brain T2* and susceptibility mapping, achieving faster imaging and improved quality compared to existing methods.

Single-cell RNA sequencing reveals recruitment of the M2-like CCL8high macrophages in Lewis lung carcinoma-bearing mice following hypofractionated radiotherapy

This study uses single-cell RNA sequencing to show hypofractionated radiotherapy recruits CCL8high macrophages, reprograms them to an immunosuppressive state, and enhances tumor growth, which can be counteracted by CCL inhibitor Bindarit.

Cryo-EM structure and biochemical analysis of human chemokine receptor CCR8

The paper determines the cryo-EM structure of ligand-free human CCR8-Gi complex and identifies key residues for agonist recognition.

E3 ligase ASB3 downregulates antiviral innate immunity by targeting MAVS for ubiquitin-proteasomal degradation

This study identifies ASB3 as an E3 ligase that suppresses antiviral immunity by ubiquitinating and degrading MAVS, thereby inhibiting IFN-I responses and promoting viral replication.

AhR ligands from LGG metabolites promote piglet intestinal ILC3 activation and IL-22 secretion to inhibit PEDV infection

This study shows LGG metabolites activate ILC3 cells via AhR to produce IL-22, which prevents PEDV infection in piglets by enhancing intestinal cell proliferation and STAT3 signaling.

Genetic heterogeneity in the Salmonella Typhi Vi capsule locus: A population genomic study from Fiji

This study examines genetic diversity in the Vi capsule locus of Salmonella Typhi in Fiji, identifying convergent evolution of tviE mutations globally and highlighting the need for further functional analysis.

Autophagy regulates tumor growth and metastasis

This study shows that autophagy inhibition stabilizes Twist1 via p62, promoting tumor growth and metastasis in skin and melanoma models.

Study on the preparation of bovine milk exosomes and the stability of lyophilized powder

This study prepares bovine milk exosomes and evaluates the stability of their lyophilized powder, showing it can be stored at room temperature for 3 months and 2-8°C for 15 months.

Uncovering the Roles of Mycobacterium tuberculosis melH in Redox and Bioenergetic Homeostasis: Implications for Antitubercular Therapy

This study investigates the role of melH in Mycobacterium tuberculosis and Mycobacterium marinum, showing its involvement in redox homeostasis, bioenergetics, and oxidative stress response, with implications for antitubercular drug development.

Prenatal Arsenite Exposure Alters Maternal Cardiac Remodeling During Late Pregnancy

This study shows that prenatal arsenic exposure reduces maternal cardiac growth and alters gene expression in late pregnancy, potentially contributing to cardiovascular disease.

Transcriptional reactivation of the tRNASer/tRNATyr gene cluster in Arabidopsis thaliana root tip (V2)

The paper identifies the tissular expression pattern of the SYY tRNA gene cluster in Arabidopsis thaliana root tips and shows its transcriptional reactivation despite DNA methylation.

Mechanisms underneath Xanthomonas citri subsp. citri promoting of Agrobacterium-mediated transient expression in citrus

This study identifies mechanisms by which Xanthomonas citri subsp. citri enhances Agrobacterium-mediated transient expression in citrus, showing that PthA4 promotes cell division and hormone regulation, and that exogenous plant hormones and cellulase improve TE efficacy.

Genome-wide Perturbation Analysis Screening System for Exosomes-Related Genes Based on the CRISPR/Cas9 Platform

The paper develops a CRISPR-UMI-based screening system to study exosome biogenesis, transport, and uptake mechanisms on a genome-wide scale.

Replication stress in activated human NK cells induces sensitivity to apoptosis

This study shows that replication stress in activated human NK cells increases apoptosis and impairs function, linking helicase deficiency to NK cell deficiency.

Identification of S1PR4 as an immune modulator for favourable prognosis in HNSCC through unbiased machine learning

This study identifies S1PR4 as a key immune modulator linked to better prognosis in HNSCC through machine learning-based subtype classification and functional analysis.

ASB3 expression aggravates inflammatory bowel disease by targeting TRAF6 protein stability and affecting the intestinal microbiota

This study shows ASB3 worsens inflammatory bowel disease by destabilizing TRAF6 and altering gut microbiota, suggesting ASB3 inhibition could be a therapeutic strategy.

Polyamine transport inhibition and cisplatin synergistically enhance tumor control through oxidative stress in murine head and neck cancer models

This study shows that combining cisplatin with AMXT-1501 enhances tumor control in HNSCC models by increasing oxidative stress and apoptosis, independent of polyamine levels.

Lysosomal mitochondrial interaction promotes tumor growth in squamous cell carcinoma of the head and neck

This study shows that lysosomal-mitochondrial interaction (LMI) promotes tumor growth in squamous cell carcinoma of the head and neck by enhancing mitochondrial complex I activity and lysosomal function.

CytoSIP: An annotated structural atlas for interactions involving cytokine or cytokine receptor

CytoSIP provides a database of cytokine-cytokine receptor interactions with SNPs, interfaces, and disease associations to aid drug design and precision medicine.

Seasonal Variation in Bacterial Community Structures of Mangrove Sediments

This study examines seasonal variations in mangrove sediment bacterial communities and identifies factors influencing their assembly mechanisms.

The novel roles of bovine milk-derived exosomes on skin anti-aging

This study investigates the effects of bovine milk-derived exosomes on human skin anti-aging, showing they enhance moisture retention and reduce wrinkles while being safe for use.