Assessment of non-linear mixed effects model-based approaches to test for drug effect using simulated data: type I error and power properties
E. Chasseloup, A. Tessier, M. O. Karlsson
This paper evaluates IMA and STD methods for drug effect testing using simulated data, finding IMA more robust to model misspecification with controlled type I error and unbiased estimates.
bioRxiv · Apr 13, 2024 · PreprintPharmacology & Toxicology