J. Richard

The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity

This paper combines three CD4-induced antibodies with a CD4-mimetic to achieve potent ADCC activity against HIV-1-infected cells.

CD4 downregulation precedes Env expression and protects HIV-1-infected cells from ADCC mediated by non-neutralizing antibodies

The paper shows CD4 downregulation precedes Env expression in HIV-1-infected cells, making them resistant to non-neutralizing antibody-mediated ADCC.

Metformin Enhances Antibody-Mediated Recognition of HIV-Infected CD4+ T-Cells by Decreasing Viral Release

This study shows metformin reduces HIV-1 virion release and increases antibody recognition of infected CD4+ T-cells by modulating BST2 and Bcl-2 expression in HIV-positive individuals on ART.

Piperidine CD4-mimetic compounds expose vulnerable Env epitopes sensitizing HIV-1-infected cells to ADCC

The paper describes piperidine-based CD4-mimetic compounds that expose HIV-1 Env epitopes, increasing sensitivity to ADCC by targeting Asp368.

Optical control of cardiac rhythm by in vivo photoactivation of an ERG channel peptide inhibitor

This study uses photopharmacology to control cardiac rhythm in vivo by uncaging a peptide inhibitor of the ERG channel, showing spatially restricted effects on heart rate and conduction.

Indoline CD4-mimetic Compounds Mediate Potent and Broad HIV-1 Inhibition and Sensitization to Antibody-dependent Cellular Cytotoxicity

This study designs and evaluates indoline-based CD4-mimetic compounds that inhibit HIV-1 more potently and broadly than existing indane-based compounds and sensitize HIV-1 to antibody-dependent cellular cytotoxicity.

Molecular basis for antiviral activity of pediatric neutralizing antibodies targeting SARS-CoV-2 Spike receptor binding domain

This study identifies two potent neutralizing antibodies, EH3 and EH8, from a pediatric patient that cross-neutralize SARS-CoV-2 variants and provide in vivo protection against the Delta VOC.

Small CD4 mimetics sensitize HIV-1-infected macrophages to antibody-dependent cellular cytotoxicity

The paper shows that small CD4 mimetics expose ADCC epitopes on HIV-1-infected macrophages, making them susceptible to antibody-dependent cellular cytotoxicity.

An S1 subunit vaccine and combination adjuvant (COVAC-1) elicits robust protection against SARS-CoV-2 challenge in African green monkeys

COVAC-1, an S1 subunit vaccine with adjuvant, protects African green monkeys from SARS-CoV-2 challenge by reducing viral load and pathology in the respiratory tract.

Characterization of human immunodeficiency virus (HIV-1) envelope glycoprotein variants selected for resistance to a CD4-mimetic compound

This study identifies HIV-1 Env variants resistant to CD4-mimetic compounds and BMS-806 by analyzing mutations that confer resistance and their effects on viral fitness and inhibitor sensitivity.

SARS-CoV-2 accessory protein ORF8 decreases antibody-dependent cellular cytotoxicity

This study shows that SARS-CoV-2 accessory protein ORF8 reduces antibody-dependent cellular cytotoxicity by binding CD16a and decreasing CD16 surface levels on monocytes and NK cells.

HIV-1 Vpu restricts Fc-mediated effector functions in vivo

This study shows that HIV-1 Vpu reduces nnAb recognition and ADCC resistance, with nnAb Fc-effector functions dependent on Env's open conformation.

VE607 Stabilizes SARS-CoV-2 Spike In the "RBD-up" Conformation and Inhibits Viral Entry

VE607 inhibits SARS-CoV-2 infection by stabilizing the RBD in the 'up' conformation and blocking S-ACE2 interaction across multiple variants.

SARS-CoV-2 Omicron Spike recognition by plasma from individuals receiving BNT162b2 mRNA vaccination with a 16-weeks interval between doses

This study evaluates how plasma from individuals with a 16-week interval between BNT162b2 mRNA vaccine doses recognizes and neutralizes the Omicron Spike compared to other variants.

Temporal associations of B and T cell immunity with robust vaccine responsiveness in a 16-week interval BNT162b2 regimen

The paper examines B and T cell immunity responses to a 16-week interval BNT162b2 vaccine regimen, finding robust immune memory and functional associations between immune components.

Detection of the HIV-1 accessory proteins Nef and Vpu by flow cytometry represents a new tool to study their functional interplay within a single infected CD4+ T cell

The paper develops a flow cytometry method to detect HIV-1 Nef and Vpu in CD4+ T cells, showing Vpu cannot compensate for Nef absence in ADCC susceptibility.

An anti-SARS-CoV-2 non-neutralizing antibody with Fc-effector function defines a new NTD epitope and delays neuroinvasion and death in K18-hACE2 mice

Covid-19 vaccine immunogenicity in people living with HIV-1

This study evaluates mRNA vaccine immunogenicity in HIV-positive individuals, finding similar anti-RBD IgG responses to controls in those with CD4 counts >250 cells/mm3, but significantly lower responses in those with <250 cells/mm3.

Across functional boundaries: making non-neutralizing antibodies to neutralize HIV-1 and mediate Fc-mediated effector killing of infected cells

This paper designs Ab-CD4 chimeric proteins that open HIV-1 Env trimers to expose non-neutralizing epitopes, enabling both neutralization and ADCC against HIV-1.

Contribution of single mutations to selected SARS-CoV-2 emerging variants Spike antigenicity

The paper evaluates how single mutations in SARS-CoV-2 Spike protein affect antigenicity and ACE2 binding in emerging variants.

Structural Basis and Mode of Action for Two Broadly Neutralizing Antibodies Against SARS-CoV-2 Emerging Variants of Concern

This study characterizes two SARS-CoV-2 antibodies effective against variants, showing their structural basis and mechanisms of neutralization.

Novel compound inhibitors of HIV-1NL4-3 Vpu

This study identifies two compounds that inhibit HIV-1NL4-3 Vpu activity but are strain-specific.

Impact of temperature on the affinity of SARS-CoV-2 Spike for ACE2

This study investigates how temperature affects SARS-CoV-2 Spike protein affinity for ACE2, finding increased binding at low temperatures, which is mitigated by the N501Y mutation.

Live imaging of SARS-CoV-2 infection in mice reveals neutralizing antibodies require Fc function for optimal efficacy

This study uses live imaging to show that neutralizing antibodies against SARS-CoV-2 need both Fab and Fc functions to effectively prevent and resolve infection in mice.

A single BNT162b2 mRNA dose elicits antibodies with Fc-mediated effector functions and boost pre-existing humoral and T cell responses

This study shows a single dose of the BNT162b2 mRNA vaccine elicits strong antibody and T cell responses, including Fc-mediated effector functions, and boosts pre-existing immunity in previously infected individuals.

Longitudinal analysis of humoral immunity against SARS-CoV-2 Spike in convalescent individuals up to 8 months post-symptom onset

This study tracks humoral immune responses in convalescent individuals up to 8 months post-SARS-CoV-2 infection, showing that IgG+ memory B cells persist while plasma antibody levels decline.

High-throughput detection of antibodies targeting the SARS-CoV-2 Spike in longitudinal convalescent plasma samples

This study tracks the decline of antibodies against the full-length SARS-CoV-2 Spike in convalescent plasma over time, showing a gradual decrease correlated with RBD-specific antibodies and days post-infection.

Major role of IgM in the neutralizing activity of convalescent plasma against SARS-CoV-2

This study shows that IgM plays a major role in neutralizing SARS-CoV-2 in convalescent plasma, with its depletion causing the greatest loss of neutralizing activity.

Cross-sectional evaluation of humoral responses against SARS-CoV-2 Spike

This study evaluates humoral responses against SARS-CoV-2 Spike in 106 infected individuals, finding persistent RBD-specific IgG and declining neutralizing activity over time.

PGC1a and Exercise Adaptations in Zebrafish

This study shows that PGC1a induces mitochondrial biogenesis and exercise-like adaptations in zebrafish, revealing conserved exercise responses and novel ETC organization.