A. Trinks

Reporter-based screening identifies RAS-RAF stabilizing mutations as drivers of resistance to broad-spectrum RAS inhibition in colorectal cancer

High-confidence calling of normal epithelial cells allows identification of a novel stem-like cell state in the colorectal cancer microenvironment

The paper develops CCISM to distinguish cancer cells from normal epithelial cells in single-cell data, identifying a novel stem-like cell state in the colorectal cancer microenvironment.

Robust detection of clinically relevant features in single-cell RNA profiles of patient-matched fresh and formalin-fixed paraffin-embedded (FFPE) lung cancer tissue

The paper compares single-cell RNA sequencing from fresh, cryopreserved, and FFPE lung cancer tissues, finding FFPE tissues can reliably detect clinically relevant features.

The single-cell transcriptional landscape of lung carcinoid tumors

This study uses single-cell RNA sequencing to analyze lung carcinoid tumors, revealing their cellular composition, gene expression profiles, and potential therapeutic targets.

Palaeogenomic analysis of black rat (Rattus rattus) reveals multiple European introductions associated with human economic history

This study uses ancient DNA to trace the introduction and population history of black rats in Europe, linking genetic changes to historical events like the Roman Empire's decline and the Plague Pandemic.

Single-cell RNA sequencing reveals distinct tumor microenvironmental patterns in lung adenocarcinoma

The paper uses single-cell RNA sequencing to identify two distinct tumor microenvironmental patterns in lung adenocarcinoma, associated with different prognostic outcomes.

Mitogen-activated protein kinase activity drives cell trajectories in colorectal cancer

The paper identifies mitogen-activated protein kinase activity as a driver of cell trajectories in colorectal cancer using single-cell transcriptomics and organoid models.