B. Obermayer

High-confidence calling of normal epithelial cells allows identification of a novel stem-like cell state in the colorectal cancer microenvironment

The paper develops CCISM to distinguish cancer cells from normal epithelial cells in single-cell data, identifying a novel stem-like cell state in the colorectal cancer microenvironment.

Multimodal profiling of peripheral blood identifies proliferating circulating effector CD4+ T cells as predictors for response to integrin α4β7-blocking therapy in patients with inflammatory bowel disease

Prdm16 mutation determines sex-specific cardiac metabolism and identifies two novel cardiac metabolic regulators

This study investigates monoallelic Prdm16 mutation in mice, revealing sex-specific cardiac metabolic dysregulation and identifying Pyroxd2 and Pbxip1 as novel metabolic regulators.

HDAC7 controls anti-viral and anti-tumor immunity by CD8+ T cells

This study shows HDAC7 regulates CD8+ T cell function by controlling survival, calcium homeostasis, and memory responses, impacting anti-viral and anti-tumor immunity in mice.

The single-cell transcriptional landscape of lung carcinoid tumors

This study uses single-cell RNA sequencing to analyze lung carcinoid tumors, revealing their cellular composition, gene expression profiles, and potential therapeutic targets.

A kinetic error filtering mechanism for enzyme-free copying of nucleic acid sequences

This paper introduces a kinetic error filtering mechanism to improve the accuracy of enzyme-free nucleic acid copying, showing it can produce exact 50mer sequences under cyclic environmental conditions.

Longitudinal omics in Syrian hamsters integrated with human data unravel complexity of moderate immune responses to SARS-CoV-2

The paper integrates longitudinal omics data from Syrian hamsters with human data to understand immune responses to SARS-CoV-2, identifying key cellular and molecular mechanisms.

Single-cell RNA sequencing reveals distinct tumor microenvironmental patterns in lung adenocarcinoma

The paper uses single-cell RNA sequencing to identify two distinct tumor microenvironmental patterns in lung adenocarcinoma, associated with different prognostic outcomes.

Mitogen-activated protein kinase activity drives cell trajectories in colorectal cancer

The paper identifies mitogen-activated protein kinase activity as a driver of cell trajectories in colorectal cancer using single-cell transcriptomics and organoid models.

Distinct immune evasion in APOBEC-enriched, HPV-negative HNSCC

The paper identifies an APOBEC-enriched subgroup of HPV-negative HNSCC with distinct immunogenic features linked to immune evasion and potential response to immunotherapy.