Focal Deletions of a Promoter Tether Activate the IRX3 Oncogene in T Cell Acute Lymphoblastic Leukemia
S. Rahman, G. Bloye, N. Farah, J. Demeulemeester, J. R. Costa, D. O'Connor, R. Pocock, A. Turna, L. Wang, S. Lee, A. K. Fielding, J. Roels, R. Jaksik, M. Dawidowska, P. V. Vlierberghe, , M. R. Mansour
The paper identifies a novel mechanism where focal deletions of an intronic element in FTO lead to IRX3 activation in T-ALL through enhancer hijacking.
bioRxiv · Feb 6, 2024Cancer Biology