A. Gutierrez

Vesicle-mediated mitochondrial clearance underlies an actionable metabolic vulnerability in triple-negative breast cancer

The paper identifies a metabolic vulnerability in triple-negative breast cancer through sphingolipid metabolism, showing that targeting this pathway with eliglustat reduces tumor growth and improves survival.

Focal Deletions of a Promoter Tether Activate the IRX3 Oncogene in T Cell Acute Lymphoblastic Leukemia

The paper identifies a novel mechanism where focal deletions of an intronic element in FTO lead to IRX3 activation in T-ALL through enhancer hijacking.

Oxycodone Self-Administration in Female Rats is Enhanced by Δ9-tetrahydrocannabinol, but not by Cannabidiol, in a Progressive Ratio Procedure

This study shows THC enhances oxycodone self-administration in female rats under progressive ratio schedules, while CBD reduces it in fixed ratio schedules.

Adult consequences of repeated nicotine and Δ9-tetrahydrocannabinol (THC) vapor inhalation in adolescent rats

This study examines the long-term effects of adolescent nicotine and THC vapor exposure in rats, finding lasting impacts on activity and drug sensitivity into adulthood.

Rats Chasing the Dragon: A new heroin inhalation method

This study demonstrates that vaporized heroin can be effectively administered to rats via inhalation, producing antinociceptive effects and self-administration behavior similar to other routes.

African rice (Oryza glaberrima) genomic introgressions impacting upon panicle architecture in Asian rice (O. sativa) lead to the identification of key QTLs

The paper identifies QTLs associated with panicle architecture traits in Asian rice by introgressing African rice genomic segments and analyzing phenotypic variations.

Adult consequences of repeated nicotine vapor inhalation in adolescent rats

This study examines the long-term behavioral effects of adolescent nicotine vapor exposure in rats, finding increased nicotine self-administration in females but minimal impact on locomotor activity.

Induced ligno-suberin vascular coating and tyramine-derived hydroxycinnamic acid amides restrict Ralstonia solanacearum colonization in resistant tomato roots

This study identifies structural barriers in resistant tomato roots that restrict Ralstonia solanacearum colonization and slow disease progression.

Salp blooms increase carbon export 5-fold in the Southern Ocean

This study shows salp blooms increase carbon export by 5-fold in the Southern Ocean, enhancing BCP efficiency to 28%.

On-tissue spatial proteomics integrating MALDI-MS imaging with shotgun proteomics reveals soy consumption-induced biomarkers in a fragile X syndrome mouse model

The long-term effects of repeated heroin vapor inhalation during adolescence on measures of nociception and anxiety-like behavior in adult Wistar rats

This study examines the long-term effects of adolescent heroin vapor inhalation on nociception and anxiety-like behavior in adult rats, finding persistent physiological and behavioral changes.

Aβ oligomers trigger necroptosis-mediated neurodegeneration via microglia activation in Alzheimer's disease.

This study shows Aβ oligomers induce necroptosis in neurons via microglia activation, leading to neurodegeneration in Alzheimer's disease, and suggests necroptosis inhibition as a potential therapeutic target.

Behavioral effects of ethanol in the Red Swamp Crayfish (Procambarus clarkii)

This study evaluates the behavioral effects of ethanol in Red Swamp Crayfish, showing dose-dependent changes in locomotion and anxiety-like behavior.

Vapor exposure to Δ9-tetrahydrocannabinol (THC) slows locomotion of the Maine Lobster (Homarus americanus)

This study exposes Maine lobsters to THC vapor and finds reduced locomotion but minimal effect on nociception.

THC modifies the impact of heroin delivered by vapor inhalation in rats

This study investigates the interaction between heroin and THC in rats, finding additive effects on thermal nociception but opposing effects on temperature and activity.

A vapor exposure method for delivering heroin alters nociception, body temperature and spontaneous activity in female and male rats

This paper develops a vapor exposure method to deliver heroin to rats, showing it alters nociception, body temperature, and activity in both sexes.

In Situ Unzipping of Long, High Molecular Weight DNA in Solid State Nanopores

This study investigates the in situ unzipping of long DNA molecules through nanopores, demonstrating longer translocation without secondary structures than previously reported.

Female rats self-administer heroin by vapor inhalation

This study shows that female rats self-administer heroin via e-cigarette vapor, producing anti-nociceptive effects similar to intravenous administration and inducing withdrawal-like anxiety.

Creatine transporter knockout mice (Slc6a8) show increases in serotonin-related proteins and are resilient to learned helplessness

This study shows that creatine transporter knockout mice exhibit increased serotonin-related proteins and resilience to learned helplessness, suggesting a complex role for creatine in affective disorders and serotonin neurotransmission.

Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias

This study identifies a synthetic lethal interaction between Wnt pathway activation and asparaginase in drug-resistant leukemias, showing that Wnt/STOP signaling can sensitize resistant cells to asparaginase.

Acute myeloid/T-lymphoblastic leukemia (AMTL): A distinct category of acute leukemias with common pathogenesis in need of improved therapy

This paper identifies a new leukemia subtype, AMTL, with shared myeloid and T-cell features, common mutations, and potential for improved therapy.