Intraperitoneal activation of myeloid cells clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer
N. Zhang, B. Murphy, T. Miyamoto, B. Manning, G. Mirji, A. Ugolini, T. Kannan, K. Hamada, Y. Zhu, D. Claiborne, L. Huang, R. Zhang, Y. Nefadova, A. Kossenkov, F. Veglia, R. Shinde
The paper shows that intraperitoneal administration of β-glucan and IFNγ clears ascites and induces IL27-dependent tumor regression in metastatic ovarian cancer models.
bioRxiv · Jun 25, 2024 · PreprintImmunology