K. Hamada

Intraperitoneal activation of myeloid cells clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer

The paper shows that intraperitoneal administration of β-glucan and IFNγ clears ascites and induces IL27-dependent tumor regression in metastatic ovarian cancer models.

Pharmacometabolomics reveals urinary diacetylspermine as a biomarker of doxorubicin effectiveness in triple negative breast cancer

A triple-negative matrix-producing breast carcinoma is arrested by tumor-targeting Salmonella typhimurium A1-R in a PDOX model

This study evaluates the efficacy of Salmonella typhimurium A1-R in arresting tumor growth in a triple-negative matrix-producing breast carcinoma PDOX model.

Histone H3K4me3 and H3K9me3 are super over-methylated in soft tissue sarcoma compared to normal muscle in patient-derived xenograft (PDX) mouse models: an indicator of cancer methionine addiction

Structural basis of the regulation of normal and oncogenic methylation of nucleosomal histone H3 Lys36 by NSD2

This study determines the cryo-EM structure of NSD2 bound to a nucleosome and identifies oncogenic mutations that increase its catalytic activity by altering the autoinhibitory loop conformation.

The linkage of methionine addiction, overmethylation of histone H3 lysines and malignancy demonstrated when cancer cells revert to methionine-independence

The paper shows that methionine-independent cancer cell revertants have reduced histone H3 lysine trimethylation and lower tumorigenicity and metastatic potential compared to methionine-addicted parental cells.

Removal of repressive histone marks creates epigenetic memory of recurring heat in Arabidopsis

The paper shows that JMJ proteins remove repressive histone marks in Arabidopsis, enabling epigenetic memory of heat exposure to improve heat tolerance.