N. Zhang

Spatiotemporal transcriptomic profiling reveals the dynamic immunological landscape of alveolar echinococcosis

This study uses spatiotemporal transcriptomics to analyze immune dynamics in E. multilocularis infected mouse liver, identifying key immune cell roles and shifts in immune strategy during infection.

Related PP2C phosphatases Pic3 and Pic12 negatively regulate immunity in tomato to Pseudomonas syringae

This study identifies Pic3 and Pic12 as PP2C phosphatases that negatively regulate tomato immunity against Pseudomonas syringae through flagellin-independent pathways.

Bioorthogonal labeling and enrichment of histone monoaminylation reveal its accumulation and regulatory function in cancer cell chromatin

This study develops chemical probes to label and enrich histone monoaminylation, revealing its enrichment in cancer tissues and its role in chromatin architecture regulation.

Targeted protein degradation of the CPSF complex by benzoxaboroles through sumoylation

This study identifies CPSF3 as a target of benzoxaboroles in trypanosomatids, showing that BoBs induce sumoylation-dependent degradation of CPSF complex members, leading to reduced mRNA levels.

A longitudinal single-cell and spatial multiomic atlas of pediatric high-grade glioma

This study creates a longitudinal multiomic atlas of pediatric high-grade glioma, revealing distinct tumor cell states and therapeutic targets not seen in adult glioblastoma.

PbrSYP71 regulates pollen tube growth by maintaining uneven distribution of the ER in Pyrus

This study identifies PbrSYP71 as a pollen tube-specific syntaxin that maintains uneven ER distribution by tethering ER to F-actin, promoting pollen tube growth in pear.

Cholesterol biosynthesis inhibition synergizes with AKT inhibitors in triple-negative breast cancer

This study identifies a synergistic effect between AKT inhibitors and pitavastatin in killing triple-negative breast cancer cells by targeting cholesterol trafficking.

Role of Staphylococcus aureus Buoyant Density in the Development of Biofilm Associated Antibiotic Resistance

This study shows that Staphylococcus aureus cells with lower buoyant density resist antibiotics more and form biofilms at air-liquid interfaces, while higher buoyant density cells are more antibiotic-sensitive and form biofilms on liquid-solid interfaces.

Battery-Free Optoelectronic Patch for Photodynamic and Light Therapies in Treating Bacteria-Infected Wounds

This paper introduces a battery-free optoelectronic patch for photodynamic and light therapies to treat bacterial infections, showing reduced bacterial load and enhanced tissue regeneration in animal models.

Complex biophysical changes and reduced neuronal firing in an SCN8A variant associated with developmental delay and epilepsy

This study characterizes the biophysical and neurophysiological effects of the SCN8A p.(Gly1625Arg) mutation, showing a complex mix of gain-and loss-of-function properties leading to reduced neuronal firing.

Epithelial organoid supports resident memory CD8 T cell differentiation

This paper develops a murine vaginal epithelial organoid system that supports CD8 T cell differentiation into resident memory T cells in vitro, showing phenotypic and transcriptional similarity to in vivo TRM.

Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting

This study shows repeated Omicron exposures reduce immune imprinting from wildtype vaccines, leading to higher neutralizing antibodies against XBB variants.

High clonal diversity and spatial genetic admixture in early prostate cancer and surrounding normal tissue

Dissecting Multiparametric Cerebral Hemodynamics using Integrated Ultrafast Ultrasound and Multispectral Photoacoustic Imaging

The paper introduces a multimodal imaging platform to measure multiple cerebral hemodynamic parameters with high spatiotemporal resolution and applies it to study brain responses to hypercapnia.

Heterogeneity in Neutrophil Extracellular Traps from Healthy Human Subjects

This study examines NET composition variability across healthy individuals and finds DNA content correlates with NET components and epithelial barrier disruption.

Melanophilin mediates the association of myosin-5a with melanosome via three distinct interactions

This study identifies a third interaction between Myo5a and Mlph, involving the exon-G region of Myo5a and Mlph-ABD, which is required for melanosome association.

Beta-aminopropionitrile Induces Distinct Pathologies in the Ascending and Descending Thoracic Aortic Regions of Young Mice

This study shows that BAPN induces distinct aortic pathologies in the ascending and descending thoracic aortas of young mice, with different structural and cellular changes in each region.

Single-cell RNA sequencing unveils the hidden powers of zebrafish kidney for generating both hematopoiesis and adaptive antiviral immunity

This study uses single-cell RNA sequencing to show zebrafish kidney cells can generate both blood cells and adaptive antiviral immunity, acting as a dual-functional organ.

Working together to control mutation: how collective peroxide detoxification determines microbial mutation rate plasticity

This study identifies hydrogen peroxide detoxification as the mechanism behind density-dependent mutation rate plasticity in microbial populations.

Cardiac disease diagnosis based on GAN in case of missing data

This paper proposes AGAN, a GAN-based method for filling missing data in cardiac disease datasets, improving data quality and downstream classification accuracy.

Natural variation of immune epitopes reveals intrabacterial antagonism

The paper analyzes natural variation in immune epitopes across bacterial genomes to reveal a mechanism of intrabacterial immune evasion.

Helper NLRs Nrc2 and Nrc3 act co-dependently with Prf/Pto and activate MAPK signaling to induce immunity in tomato

This study shows that Nrc2 and Nrc3 helper NLRs work with Prf/Pto to activate MAPK signaling and induce immunity in tomato against Pseudomonas syringae pv. tomato.

An ACE2 decamer viral trap as a durable intervention solution for current and future SARS-CoV

This paper introduces an ACE2 decamer viral trap that neutralizes multiple SARS-CoV-2 variants and related coronaviruses through inhalation, showing durability and effectiveness in preclinical models.

Toxicogenomic analysis of the carcinogenic potential of plastic additives

This study analyzes the carcinogenic potential of 2,712 plastic additives using toxicogenomic methods, finding over 150 known carcinogens and most lacking carcinogenicity data.

Levy statistics define anxiety and depression in mice subjected to chronic stress

This paper identifies Levy statistics as a marker for anxiety and depression in mice under chronic stress, using movement patterns and machine learning for classification.

Spatially-resolved single-cell atlas of ascidian endostyle provides insights into the origin of vertebrate pharyngeal organs

The paper constructs a spatially-resolved single-cell atlas of the ascidian endostyle, identifying new cell types and evolutionary insights into vertebrate pharyngeal organs.

Competence for transcellular infection in the root cortex involves a post-replicative, cell-cycle exit decision in Medicago truncatula

The paper identifies a cell-cycle exit decision in Medicago truncatula root cortex cells that facilitates transcellular infection by rhizobia.

Resolving the developmental mechanisms of coagulation abnormalities characteristic of SARS-CoV2 based on single-cell transcriptome analysis

This study uses single-cell transcriptome analysis to identify immune and metabolic mechanisms underlying coagulation abnormalities in SARS-CoV-2 infection.

Prospectively predicting BPaMZ Phase IIb outcomes using a translational preclinical mouse to human platform

This paper predicts outcomes of BPaMZ tuberculosis treatment regimens using a translational preclinical mouse to human platform, showing potential to shorten treatment duration and prevent relapse.

Induction of transmucosal protection by oral vaccination with an attenuated Chlamydia

This study evaluates an attenuated Chlamydia muridarum mutant as an oral vaccine that induces transmucosal immunity against genital and airway infections but not gastrointestinal colonization.