Author

A. Kossenkov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Immunology· 2 Microbiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Assay:bulk RNA-seq· 5 Organism:mouse· 5 Organism:human· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:drug response / drug discovery· 3

Frequent Co-Authors

D. Maestri· 2 shared G. M. Alicea· 2 shared I. Tempera· 2 shared L. B. Caruso· 2 shared M. E. Fane· 2 shared M. Herlyn· 2 shared M. Xiao· 2 shared Q. Liu· 2 shared

Activity by Year

2019-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCancer Biology

D. Maestri

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Plasma Glycomic Markers of Accelerated Biological Aging During Chronic HIV Infection

L. B. Giron, Q. Liu, O. S. Adeniji, X. Yin, T. Kannan, J. Ding, D. Y. Lu, S. Langan, J. Zhang, J. L. L. C. Azevedo, S. H. Li, S. Shalygin, P. Azadi, D. B. Hanna, I. Ofotokun, , M. A. Mohsen

This study identifies glycomic alterations in HIV-positive individuals that correlate with accelerated aging and comorbidities, suggesting potential biomarkers for early detection.

bioRxiv · Aug 9, 2023 · PreprintMicrobiology

PARP1 Inhibition Halts EBV+ Lymphoma Progression by Disrupting the EBNA2/MYC Axis

G. Napoletani, S. S. Soldan, T. Kannan, S. Preston-Alp, P. Vogel, D. Maestri, L. B. Caruso, A. Kossenkov, A. Sobotka, P. M. Lieberman, I. Tempera

This study shows that PARP1 inhibition reduces EBV-driven lymphoma progression by disrupting the EBNA2/MYC axis in a mouse model.

bioRxiv · Jul 5, 2023 · PreprintCancer Biology

Age-related increases in fibroblasts-secreted IGFBP2 increase melanoma cell invasion and lipid synthesis.

G. M. Alicea, M. E. Portuallo, P. Patel, M. E. Fane, A. Carey, D. W. Speicher, A. Kossenkov, V. W. Rebecca, D. Wirtz, A. T. Weeraratna

This study shows that aged fibroblasts secrete more IGFBP2, which promotes melanoma cell invasion and lipid synthesis, and that neutralizing IGFBP2 reduces tumor growth and metastasis.

bioRxiv · May 2, 2023Cancer Biology

Perinuclear damage from nuclear envelope deterioration elicits stress responses that contribute to LMNA cardiomyopathy

K. Sikder, E. Phillips, Z. Zhong, N. Wang, J. Saunders, D. Mothy, A. Kossenkov, T. Schneider, Z. Nichtova, G. Csordas, K. B. Margulies, J. C. Choi

This study identifies perinuclear stress responses from nuclear envelope deterioration as contributors to LMNA cardiomyopathy using a mouse model and translatome profiling.

bioRxiv · Feb 14, 2023 · PreprintCell Biology

Dasatinib Resensitizes MAPK Inhibitor Efficacy in Standard-of-Care Relapsed Melanomas

V. W. Rebecca, M. Xiao, A. Kossenkov, T. Godok, G. S. Brown, D. Fingerman, G. M. Alicea, M. Wei, H. Ji, J. Bravo, Y. Chen, M. E. Fane, J. Villanueva, K. L. Nathanson, Q. Liu, , M. Herlyn

The paper identifies dasatinib as effective in restoring BRAFi/MEKi antitumor efficacy in 70% of resistant PDX models by targeting proteins involved in therapy escape.

bioRxiv · Jan 20, 2023 · PreprintCancer Biology

The Nuclear Lamina binds the EBV genome during latency and regulates viral gene expression

L. B. Caruso, R. Guo, K. Keith, J. Madzo, D. Maestri, S. Boyle, J. Wasserman, A. Kossenkov, B. Gewurz, I. Tempera

bioRxiv · Aug 5, 2021Microbiology

Systematic Establishment of Robustness and Standards in Patient-Derived Xenograft Experiments and Analysis

Y. A. Evrard, A. SRIVASTAVA, J. Randjelovic, S. Arunachalam, C. J. Bult, H. Chen, L. Chen, M. Davies, S. Davies, B. Davis-Dusenbery, J. DiGiovanna, L. Ding, J. H. Doroshow, B. Fang, C. Frech, , J. Morris

The paper tests the reproducibility of PDX drug responses and sequence results across different labs using standardized protocols and workflows.

bioRxiv · Oct 2, 2019Cancer Biology

Vaccine-induced ICOS+CD38+ cTfh are sensitive biosensors of age-related changes in inflammatory pathways

R. S. Herati, L. V. Silva, L. A. Vella, A. Muselman, C. Alanio, B. Bengsch, R. Kurupati, S. Kannan, S. Manne, A. Kossenkov, D. Canaday, S. Doyle, H. Ertl, K. Schmader, E. J. Wherry

The paper uses transcriptional profiling to show that vaccine-induced ICOS+CD38+ cTfh cells in elderly show inflammation-related gene signatures and age-associated biological changes.

bioRxiv · Jul 24, 2019 · PreprintImmunology

IL-27 receptor signaling regulated stress myelopoiesis drives Abdominal Aortic Aneurysm development

I. Peshkova, T. Aghayev, A. Fatkhullina, P. Makhov, S. Eguchi, Y. F. Tan, A. Kossenkov, S. Sykes, E. Koltsova

This study shows that IL-27 receptor signaling in hematopoietic stem cells drives abdominal aortic aneurysm development by promoting myeloid cell accumulation.

bioRxiv · Feb 20, 2019Immunology