Cancer BiologybioRxiv
Targeting the translational machinery in gastrointestinal stromal tumors (GIST) - a new therapeutic vulnerability
D. M. Lee, A. Sun, S. S. Patil…·A. Duensing
This study shows that homoharringtonine (HHT) effectively inhibits KIT-dependent GIST growth by reducing protein synthesis, even in imatinib-resistant models.
DOI 10.1038/s41598-022-12000-2