Author

A. Duensing

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

D. M. Lee· 2 shared J. L. Rausch· 2 shared S. S. Patil· 2 shared A. A. Ali· 1 shared A. A. Amir· 1 shared A. Agha· 1 shared A. Angione· 1 shared A. C. Tarbay· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCancer Biology

D. M. Lee

Mutual co-authors in cluster

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3 papers

Recent·Most cited

All-trans retinoic acid induces durable tumor immunity in IDH-mutant gliomas by rescuing transcriptional repression of the CRBP1-retinoic acid axis

A. Rao, X. Zhang, A. Cillo, J. H. Sussman, P. Sandlesh, A. C. Tarbay, A. N. Mallela, C. Cardello, K. Krueger, J. Xu, A. Li, J. Xu, J. Patterson, E. Akca, A. Angione, , N. M. Amankulor

This study shows that all-trans retinoic acid (ATRA) improves immune response in IDH-mutant gliomas by restoring the RA pathway, leading to tumor regression in mouse models and a clinical trial for human patients.

bioRxiv · Apr 9, 2024 · PreprintCancer Biology

Targeting the translational machinery in gastrointestinal stromal tumors (GIST) - a new therapeutic vulnerability

D. M. Lee, A. Sun, S. S. Patil, L. Liu, A. V. Rao, P. T. Trent, A. A. Amir, C. Liu, J. L. Rausch, L. D. Presutti, A. Kaczorowski, F. Schneider, N. Amankulor, M. Shuda, A. Duensing

This study shows that homoharringtonine (HHT) effectively inhibits KIT-dependent GIST growth by reducing protein synthesis, even in imatinib-resistant models.

bioRxiv · Sep 1, 2021Cancer Biology

Differential antitumor activity of compounds targeting the ubiquitin-proteasome machinery in gastrointestinal stromal tumor (GIST) cells

J. L. Rausch, A. A. Ali, D. M. Lee, Y. K. Gebreyohannes, K. R. Mehalek, A. Agha, S. S. Patil, Y. Tolstov, J. Wellens, H. S. Dhillon, K. R. Makielski, M. Debiec-Rychter, P. Schoeffski, A. Wozniak, A. Duensing

This study evaluates second-generation proteasome inhibitors and ubiquitination regulators for their efficacy against imatinib-resistant GIST cells, finding that 20S proteasome inhibitors are effective while others show limited activity.

bioRxiv · Jan 9, 2020Cancer Biology