A transcriptionally active lipid vesicle encloses theinjected Chimalliviridae genome in early infection
E. Armbruster, P. Rani, J. Lee, N. Klusch, J. Hutchings, L. Y. Hoffman, H. Buschkaemper, E. Enustun, B. Adler, K. Inlow, A. VanderWal, M. Y. Hoffman, D. Daksh, A. Aindow, A. Deep, , J. Pogliano
The paper shows that Chimalliviridae form a lipid membrane-bound EPI vesicle during early infection, which hosts transcription of the phage genome, and demonstrates the necessity of a second compartment, the phage nucleus, for genome replication.
bioRxiv · Sep 20, 2023 · PreprintCell Biology