P. Rani

A transcriptionally active lipid vesicle encloses theinjected Chimalliviridae genome in early infection

The paper shows that Chimalliviridae form a lipid membrane-bound EPI vesicle during early infection, which hosts transcription of the phage genome, and demonstrates the necessity of a second compartment, the phage nucleus, for genome replication.

HuR enhances SARS-CoV-2 non-structural protein translation through the genomic 5'-UTR, by promoting polypyrimidine tract-binding protein binding

This paper identifies HuR's role in enhancing SARS-CoV-2 non-structural protein translation via the 5'-UTR by promoting PTB binding, while suppressing structural protein translation, and shows potential therapeutic targeting of HuR.

A natural broad-spectrum inhibitor of enveloped virus entry, effective against SARS-CoV-2 and Influenza A Virus in preclinical animal models.

This paper identifies picolinic acid as a broad-spectrum antiviral that inhibits enveloped virus entry, showing efficacy against SARS-CoV-2 and Influenza A Virus in animal models.

A multifunctional type IA DNA/RNA topoisomerase with RNA hydrolysis and rRNA processing activities from Mycobacterium smegmatis and Mycobacterium tuberculosis

This study identifies a multifunctional DNA/RNA topoisomerase in mycobacteria that performs RNA hydrolysis and rRNA processing, highlighting its dual catalytic roles in RNA metabolism.