E. Enustun

An essential and highly selective protein import pathway encoded by nucleus-forming phage

This paper identifies components of a novel protein import pathway in phages, revealing a mechanism for selective protein trafficking into the phage nucleus.

Architecture and infection-sensing mechanism of the bacterial PARIS defense system

This study reveals the molecular architecture and infection-sensing mechanism of the bacterial PARIS defense system, showing how it is triggered by a phage counterdefense protein.

A phage nucleus-associated RNA-binding protein is required for jumbo phage infection

This study identifies ChmC, a phage protein that binds RNA and facilitates mRNA transport through the phage nucleus-like compartment, essential for infection.

A transcriptionally active lipid vesicle encloses theinjected Chimalliviridae genome in early infection

The paper shows that Chimalliviridae form a lipid membrane-bound EPI vesicle during early infection, which hosts transcription of the phage genome, and demonstrates the necessity of a second compartment, the phage nucleus, for genome replication.

Bacterial Shedu immune nucleases share a common enzymatic core regulated by diverse sensor domains

The paper identifies the structural basis for activation of Bacillus cereus Shedu nuclease and reveals diversity in its N-terminal regulatory domains across 8,000 homologs.

Identification of the bacteriophage nucleus protein interaction network

The paper identifies proteins interacting with the phage nucleus protein ChmA and describes their potential roles in genome packaging and transport.

A conserved signaling pathway activates bacterial CBASS immune signaling in response to DNA damage

The paper identifies a conserved signaling pathway in bacteria that activates CBASS immune systems in response to DNA damage through the regulation of CapH and CapP.

Architecture and self-assembly of the jumbo bacteriophage nuclear shell

The paper identifies chimallin as the primary protein forming the bacteriophage nuclear shell and characterizes its self-assembly into closed compartments.

Subcellular Organization of Viral Particles During Maturation of Nucleus-Forming Jumbo Phage

The paper visualizes the subcellular organization of mature viral particles in nucleus-forming jumbo phages, revealing a structured assembly process called phage bouquets.

Bacterial Cytological Profiling Identifies Rhodanine-containing PAINS Analogs as Specific Inhibitors of E. coli Thymidylate Kinase in Vivo

Isolation and characterization of Streptomyces bacteriophages and Streptomyces strains encoding biosynthetic arsenals

This study identifies novel Streptomyces strains and phages with potential for antibiotic discovery and genetic manipulation.