J. Pogliano

The paper shows a mobile intron in bacteriophage ΦPA3 uses its homing endonuclease to interfere with co-infecting phage ΦKZ, providing a competitive reproductive advantage.

This study identifies ChmC, a phage protein that binds RNA and facilitates mRNA transport through the phage nucleus-like compartment, essential for infection.

The paper shows that Chimalliviridae form a lipid membrane-bound EPI vesicle during early infection, which hosts transcription of the phage genome, and demonstrates the necessity of a second compartment, the phage nucleus, for genome replication.

The paper identifies proteins interacting with the phage nucleus protein ChmA and describes their potential roles in genome packaging and transport.

The paper identifies jumbo and non-jumbo phages effective against XDR Pseudomonas aeruginosa isolates causing eyedrop-associated infections.

The paper identifies a core genome of nucleus-forming bacteriophages and characterizes the replication mechanism of Erwinia phage RAY.

The paper identifies chimallin as the primary protein forming the bacteriophage nuclear shell and characterizes its self-assembly into closed compartments.

The paper identifies a cytoskeletal vortex in E. coli jumbo phage Goslar that drives phage nucleus rotation, similar to eukaryotic structures.

The paper visualizes the subcellular organization of mature viral particles in nucleus-forming jumbo phages, revealing a structured assembly process called phage bouquets.

The paper investigates nuclear transport in phage infection systems, finding that GFPmut1 can be selectively transported into the {Phi}KZ phage nucleus, with specific amino acid residues identified for this process.

This paper identifies 29 independently modulated gene sets in S. aureus using ICA, linking them to regulators and physiological responses.

This study identifies novel Streptomyces strains and phages with potential for antibiotic discovery and genetic manipulation.

This study examines how MDR A. baumannii responds to azithromycin in different growth conditions using multiple analytical techniques.

The paper examines vancomycin's effect on HA-MRSA USA100 strains using bacteriological and physiological media through growth curves, RNA sequencing, and exo-metabolomics.

This study investigates how nafcillin affects HA-MRSA D592 in different media types, revealing media-dependent antibiotic activity through multi-dimensional analysis.

This study shows that perturbing RNA polymerase activity in E. coli leads to biphasic growth and increased tolerance to antibacterial stresses.