A. Deep

Complex compositional and cellular response of river sediment microbiomes to multiple anthropogenic stressors

This study shows river sediment microbiomes are highly sensitive to reduced flow velocity, leading to altered community compositions and stress responses that recover after two weeks.

Phospho-KNL-1 recognition by a TPR domain targets the BUB-1/BUB-3 complex to C. elegans kinetochores

This study shows that the BUB-1 TPR domain directly binds phosphorylated KNL-1 motifs, essential for BUB-1-BUB-3 localization and function in C. elegans.

Architecture and infection-sensing mechanism of the bacterial PARIS defense system

This study reveals the molecular architecture and infection-sensing mechanism of the bacterial PARIS defense system, showing how it is triggered by a phage counterdefense protein.

Phosphorylation regulates tau's phase separation behavior and interactions with chromatin

This study shows phosphorylation disrupts tau's ability to undergo phase separation and interact with chromatin, potentially contributing to nuclear dysfunction in Alzheimer's disease.

A phage nucleus-associated RNA-binding protein is required for jumbo phage infection

This study identifies ChmC, a phage protein that binds RNA and facilitates mRNA transport through the phage nucleus-like compartment, essential for infection.

A transcriptionally active lipid vesicle encloses theinjected Chimalliviridae genome in early infection

The paper shows that Chimalliviridae form a lipid membrane-bound EPI vesicle during early infection, which hosts transcription of the phage genome, and demonstrates the necessity of a second compartment, the phage nucleus, for genome replication.

Bacterial Shedu immune nucleases share a common enzymatic core regulated by diverse sensor domains

The paper identifies the structural basis for activation of Bacillus cereus Shedu nuclease and reveals diversity in its N-terminal regulatory domains across 8,000 homologs.

The role of greater competitive ability in countering age disadvantages in larval competition in Drosophila melanogaster

This study shows that Drosophila melanogaster populations adapted to larval crowding better counter age disadvantages in competition than low-density controls, but differences in egg size and hatching time among these populations do not improve their performance against age-disadvantaged competitors.

Identification of the bacteriophage nucleus protein interaction network

The paper identifies proteins interacting with the phage nucleus protein ChmA and describes their potential roles in genome packaging and transport.

The small mycobacterial ribosomal protein, bS22, modulates aminoglycoside accessibility to its 16S rRNA helix-44 binding site

This study shows that the mycobacterial ribosomal protein bS22 modulates aminoglycoside binding to the 16S rRNA helix-44 site, influencing antibiotic resistance.

PLK-1 tethered on BUB-1 directs CDC-20 kinetochore recruitment to ensure timelyembryonic mitoses

This study shows that PLK-1 tethered on BUB-1 promotes CDC-20 recruitment to kinetochores, ensuring timely mitosis in C. elegans embryos through phosphoregulation.

Architecture and self-assembly of the jumbo bacteriophage nuclear shell

The paper identifies chimallin as the primary protein forming the bacteriophage nuclear shell and characterizes its self-assembly into closed compartments.

Density-dependent selection in Drosophila: evolution of egg size and hatching time

This study shows that egg size and hatching time evolve in response to different larval crowding regimes in Drosophila, with egg size consistently correlating with increased competitive ability.

Structures of the human mitochondrial ribosome recycling complexes reveal distinct mechanisms of recycling and antibiotic resistance