A. Venkatesan

Phytochemical studies and Antimicrobial Activity on the leaves of Antigonon leptopus and Ecbolium viridae

This study evaluates the antibacterial activity of methanol, ethanol, and acetone leaf extracts from Antigonon leptopus and Ecbolium viridae against Gram-positive and Gram-negative bacteria using agar well diffusion.

Lysosomal Degradation Pathways Target Mutant Calreticulin and the Thrombopoietin Receptor in Myeloproliferative Neoplasms

This study shows that mutant calreticulin induces lysosomal degradation of the thrombopoietin receptor in MPNs, and drug-induced lysosomal activation reduces mutant protein levels and pathogenic effects.

Daam1 negatively regulates USP10 activity

This study identifies Daam1 as a novel binding partner of USP10, showing that Daam1 negatively regulates USP10's deubiquitinase activity and integrin homeostasis during wound healing.

Mpl is activated by dimers of MPN-linked calreticulin mutants stabilized by disulfide bonds and ionic interactions

This study identifies how mutated calreticulin (CRTDel52) forms dimers stabilized by disulfide bonds and ionic interactions, leading to Mpl activation and cytokine-independent cell proliferation in MPNs.

Expression of varicella-zoster virus VLT-ORF63 fusion transcript induces broad viral gene expression during reactivation from neuronal latency

This study identifies VLT-ORF63 fusion transcripts in VZV-infected neurons, showing they drive lytic gene expression during reactivation from latency.

Human stem cell derived sensory neurons are positioned to support varicella zoster virus latency

This study investigates VZV latency and reactivation in human sensory neurons, finding they resist lytic infection but support latency and reactivation, mirroring in vivo conditions.