N. Castro

2.5D Actuating Substrates Enable Decoupling the Mechanical and Biochemical Effects of Muscle Exercise on Motor Neurons

This study uses 2.5D actuating substrates to show that both mechanical and biochemical effects of muscle exercise significantly influence motor neuron growth and maturation.

Structure-Activity Relationship Study Identifies a Novel Lipophilic Amiloride Derivative that Efficiently Kills Chemoresistant Breast Cancer Cells

This study identifies a novel amiloride derivative, LLC1, that shows potent cytotoxicity against chemoresistant breast cancer cell lines but limited efficacy in a metastatic mouse model.

Circulating tumor extracellular vesicles to monitor metastatic prostate cancer genomics and transcriptomic evolution

This study shows that circulating tumor extracellular vesicles can be used to monitor genomic and transcriptomic changes in metastatic prostate cancer through liquid biopsy.

Daam1 negatively regulates USP10 activity

This study identifies Daam1 as a novel binding partner of USP10, showing that Daam1 negatively regulates USP10's deubiquitinase activity and integrin homeostasis during wound healing.

Mechanical compartmentalization of the intestinal organoid enables crypt folding and collective cell migration

This study maps mechanical forces in mouse intestinal organoids, revealing how stress patterns drive crypt folding and cell migration through compartmentalization.

Co-translational protein targeting facilitates centrosomal recruitment of PCNT during centrosome maturation

The paper shows PCNT is co-translationally targeted to centrosomes during mitosis by cytoplasmic dynein, with ASPM also showing similar targeting to spindle poles.