Author

A. Viegas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

B. Frieg· 1 shared B. Guigliarelli· 1 shared C. Mota· 1 shared D. Bickel· 1 shared F. Biaso· 1 shared G. Groth· 1 shared G. Vilela-Alves· 1 shared H. Gohlke· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiophysics

B. Frieg

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2 papers

Recent·Most cited

Substrate-dependent oxidative inactivation of a W-dependent formate dehydrogenase involving selenocysteine displacement.

G. Vilela-Alves, R. R. Manuel, A. Viegas, P. Carpentier, F. Biaso, B. Guigliarelli, I. C. Pereira, M. J. Romao, C. Mota

This study investigates oxidative inactivation of W-dependent formate dehydrogenase by showing SeCys displacement and dioxygen/peroxide binding in the active site under O2 exposure with substrates.

bioRxiv · Jan 10, 2024Biochemistry

Biophysical and pharmacokinetic characterization of a small-molecule inhibitor of RUNX1/ETO tetramerization with anti-leukemic effects

M. Gopalswamy, T. Kroeger, D. Bickel, B. Frieg, S. Akter, S. Schott-Verdugo, A. Viegas, T. Pauly, M. Mayer, J. Przibilla, J. Reiners, L. Nagel-Steger, S. H. J. Smits, G. Groth, M. Etzkorn, H. Gohlke

This paper characterizes a small-molecule inhibitor of RUNX1/ETO tetramerization, showing it disrupts tetramer stability and has favorable pharmacokinetic properties for potential anti-leukemic therapy.

bioRxiv · Dec 22, 2021Biophysics