M. Mayer

Differential cell type-specific function of the aryl hydrocarbon receptor and its repressor in diet-induced obesity and fibrosis

This study investigates the cell type-specific roles of AhR and AhRR in diet-induced obesity and fibrosis, finding that AhRR deficiency protects from metabolic dysfunction and liver damage, while AhR deficiency worsens outcomes.

Comparing sparse inertial sensor setups for sagittal-plane walking and running reconstructions

This study evaluates sparse inertial sensor setups for accurate sagittal-plane motion analysis during walking and running, finding that setups with foot and thigh sensors provide reliable results.

Structural basis of Gabija anti-phage defense and viral immune evasion

This study reveals the structural basis of the Gabija anti-phage defense complex and identifies a viral immune evasion mechanism through phage-encoded Gad1.

Stuck in the weeds: Invasive grasses reduce tiger snake movement

This study examines how invasive kikuyu grass affects the movement and home range size of western tiger snakes compared to native vegetation.

Simultaneous Determination of the Size and Shape of Single α-Synuclein Oligomers in Solution

This paper uses nanopore measurements to determine the size and shape of single α-synuclein oligomers in solution, revealing stable sub-populations with specific monomer counts.

Site-specific C-terminal fluorescent labeling of Tau protein

This study develops a method to fluorescently label Tau protein at its C-terminus to avoid disrupting its microtubule-binding region, showing no significant effect on its aggregation properties.

Co-occurrence patterns and habitat selection of the mountain hare, European hare, and European rabbit in urban areas of Sweden

The paper examines co-occurrence patterns and habitat selection of three lagomorph species in Swedish urban areas using citizen science data and statistical models, finding that urban success varies among species and is influenced by environmental factors.

Structural and functional impact by SARS-CoV-2 Omicron spike mutations

This study examines the structural, functional, and antigenic properties of the SARS-CoV-2 Omicron spike protein, revealing its enhanced immune evasion and altered fusogenic capability due to mutations.

Biophysical and pharmacokinetic characterization of a small-molecule inhibitor of RUNX1/ETO tetramerization with anti-leukemic effects

This paper characterizes a small-molecule inhibitor of RUNX1/ETO tetramerization, showing it disrupts tetramer stability and has favorable pharmacokinetic properties for potential anti-leukemic therapy.

Regulation with cell size ensures mitochondrial DNA homeostasis during cell growth

The paper shows that mitochondrial DNA copy number increases with cell volume in budding yeast through nuclear-encoded factors, maintaining stable concentrations without cell-cycle regulation.

Inverse PI by NMR: Analysis of Ligand 1H-Chemical Shifts in the Protein-Bound State

The paper analyzes ligand 1H chemical shifts in the protein-bound state using NMR to study protein-ligand interactions and their conformational and solvation effects.

Previously uncharacterized rectangular bacterial structures in the dolphin mouth

The paper discovers novel rectangular bacterial structures in dolphin mouths and characterizes their morphology and potential bacterial origin through multiple methods.

Light spectra trigger divergent gene expression in barley cultivars

The paper examines how different light spectra affect gene expression in barley cultivars, identifying key transcription factors and pathways involved in light sensitivity and adaptation.

Cytokine receptor-Eb1 interaction couples cell polarity and fate during asymmetric cell division

The paper identifies a novel mechanism where the cytokine receptor Dome interacts with Eb1 to regulate spindle orientation in Drosophila GSCs, linking cell polarity to fate without involving the JAK-STAT pathway.