Author

B. Frieg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

H. Gohlke· 2 shared A. Schweinitz· 1 shared A. Viegas· 1 shared C. Sattler· 1 shared D. Bickel· 1 shared G. Groth· 1 shared J. Kusch· 1 shared J. Przibilla· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiophysics

H. Gohlke

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2 papers

Recent·Most cited

Biophysical and pharmacokinetic characterization of a small-molecule inhibitor of RUNX1/ETO tetramerization with anti-leukemic effects

M. Gopalswamy, T. Kroeger, D. Bickel, B. Frieg, S. Akter, S. Schott-Verdugo, A. Viegas, T. Pauly, M. Mayer, J. Przibilla, J. Reiners, L. Nagel-Steger, S. H. J. Smits, G. Groth, M. Etzkorn, H. Gohlke

This paper characterizes a small-molecule inhibitor of RUNX1/ETO tetramerization, showing it disrupts tetramer stability and has favorable pharmacokinetic properties for potential anti-leukemic therapy.

bioRxiv · Dec 22, 2021Biophysics

Functional and structural characterization of interactions between opposite subunits in HCN pacemaker channels

M. Kondapuram, B. Frieg, S. Yueksel, T. Schwabe, C. Sattler, M. Lelle, A. Schweinitz, R. Schmauder, K. Benndorf, H. Gohlke, J. Kusch

The paper identifies residue K464 in the C-linker of HCN2 channels as critical for stabilizing the closed state through interactions with opposite subunits, supported by mutagenesis, electrophysiology, and molecular dynamics simulations.

bioRxiv · Sep 21, 2020Biophysics