J. Reiners

Full-length structure of the host targeted bacterial effector Bep1 reveals a novel structural domain conserved in FIC effector proteins from Bartonella

The paper determines the crystal structure of Bep1, revealing a novel FIC-OB-BAS(BID) domain arrangement and its role in T4SS translocation.

The fungal protein Jps1 facilitates unconventional protein secretion through a direct phosphoinositide interaction

This study identifies Jps1 as a key protein facilitating unconventional secretion in Ustilago maydis by interacting with phosphoinositides, revealing its structural and functional roles in Cts1 export.

Integrative modeling of guanylate binding protein dimers

The paper models dimer structures of GBP proteins using integrative methods, revealing structural differences that explain functional divergence.

The periplasmic chaperone Skp prevents misfolding of the secretory lipase A from Pseudomonas aeruginosa

This study shows that Skp prevents misfolding of lipase A in Pseudomonas aeruginosa and facilitates its activation by LipH, with two binding modes identified.

Biophysical and pharmacokinetic characterization of a small-molecule inhibitor of RUNX1/ETO tetramerization with anti-leukemic effects

This paper characterizes a small-molecule inhibitor of RUNX1/ETO tetramerization, showing it disrupts tetramer stability and has favorable pharmacokinetic properties for potential anti-leukemic therapy.

A MademoiseLLE domain binding platform links the key RNA transporter to endosomes

The paper identifies MLLE domains in Rrm4 as essential for endosomal attachment, revealing a hierarchical binding platform for mRNA transport.

Mechanism of the secretion of the lanthipeptide nisin

The paper investigates the secretion mechanism of nisin, showing that NisC modulates secretion rates while NisB's presence affects it, and that NisT's activity is influenced by maturation enzymes.