BiophysicsbioRxiv
Biophysical and pharmacokinetic characterization of a small-molecule inhibitor of RUNX1/ETO tetramerization with anti-leukemic effects
M. Gopalswamy, T. Kroeger, D. Bickel…·H. Gohlke
This paper characterizes a small-molecule inhibitor of RUNX1/ETO tetramerization, showing it disrupts tetramer stability and has favorable pharmacokinetic properties for potential anti-leukemic therapy.
DOI 10.1038/s41598-022-17913-6