A. von Gottberg

The paper uses genomic data to study geographic spread and fitness changes in Streptococcus pneumoniae strains before and after vaccine implementation.

The paper identifies 13 rare mutations in the Omicron S-gene that cluster in functionally important regions and likely impact Spike function, suggesting cooperative interactions that mitigate fitness costs.

This study shows that SARS-CoV-2 501Y.V2 pseudovirus escapes neutralization by South African convalescent plasma but not binding, suggesting potential for reinfection and reduced vaccine efficacy.

The paper identifies a novel tetracycline resistance gene tet(S/M) in a multidrug-resistant pneumococcal lineage in South Africa and links its spread to HIV treatment and vaccine implementation.

This study analyzes global serotype 3 pneumococcal isolates to show a recent emergence of Clade II with antibiotic resistance and antigenic diversity, not linked to PCV13 usage.