De novo Protein Sequence Design Based on Deep Learning and Validation on CalB Hydrolase
J. Mu, Z. Li, B. Zhang, Q. Zhang, J. Iqbal, A. Wadood, T. Wei, Y. Feng, H. Chen
The paper designs novel protein sequences using a Graphormer-based model and validates them on CalB hydrolase, achieving 1.7x higher specific activity than the wild type.
bioRxiv · Aug 1, 2023 · PreprintBiochemistry