T. Wei

A foundation model for generalizable cancer diagnosis and survival prediction from histopathological images

This paper introduces BEPH, a lightweight foundation model for cancer diagnosis and survival prediction from histopathological images, showing improved performance over existing models with limited data.

Engineering PEG10 assembled endogenous virus-like particles with genetically encoded neoantigen peptides for cancer vaccination

This paper develops ePAC, a cancer vaccine using PEG10-based virus-like particles to deliver neoantigens and adjuvants, showing efficacy in preclinical models.

Discovery of Alkenyl Oxindole as a Novel PROTAC Moiety for Targeted Protein Degradation via CRL4DCAF11 Recruitment

The paper develops JQ1-alkenyl oxindole conjugates that degrade BRD4 via the ubiquitin-proteasome system and recruits CRL4DCAF11, identifying HL435 as a potent antitumor lead.

Deciphering the Cofilin Oligomers via Intermolecular Disulfide Bond Formation: A Coarse-grained Molecular Dynamics Approach to Understanding Cofilin's Regulation on Actin Filaments

This study uses molecular dynamics simulations to explore cofilin dimer structures formed via disulfide bonds and their interactions with actin filaments.

M1 Macrophage-Related Genes Model for NSCLC Immunotherapy Response Prediction

This study develops a model using M1 macrophage-related genes to predict immunotherapy response and prognosis in advanced NSCLC patients.

Pathogenic mitochondrial DNA mutations inhibit melanoma metastasis

This study shows that pathogenic mtDNA mutations in melanoma cells reduce metastasis by limiting circulation entry, despite promoting tumor growth.

De novo Protein Sequence Design Based on Deep Learning and Validation on CalB Hydrolase

The paper designs novel protein sequences using a Graphormer-based model and validates them on CalB hydrolase, achieving 1.7x higher specific activity than the wild type.

A flexible, efficient, and scalable platform to produce circular RNAs as new therapeutics

This paper develops a self-catalyzed system to produce stable, low-immunogenic circRNAs for therapeutic protein expression, showing improved efficacy compared to linear mRNAs.

A Potential Novel COVID-19 Vaccine With RBD-HR1/HR2 Hexamer Structure

This paper introduces a novel COVID-19 vaccine based on a RBD-HR1/HR2 hexamer structure that induces high neutralizing antibody titers and alternative antibodies targeting the HR1 region in mice.

Trivial Excitation Energy Transfer to Carotenoids is an Unlikely Mechanism for Non-Photochemical Quenching in LHCII

This study challenges the idea that trivial energy transfer to carotenoid S1 states is the main mechanism of NPQ in LHCII, showing it is unlikely due to insufficient pigment movement and overestimated S1 oscillator strength.

Revealing the function of HMGB1 N-terminal acetylation by a protein semi-synthesis approach

This study uses a semi-synthesis approach to generate N-terminal acetylated HMGB1 proteins and shows that this modification affects its interaction with heparin and stability.

Programmable RNA base editing with a single gRNA-free enzyme

This paper introduces a gRNA-free RNA editing system called REWIRE that achieves high editing efficiency and low off-target effects in human and mouse cells.

Phosphorus stress induces the synthesis of novel glycolipids in Pseudomonas aeruginosa that confer protection against a last-resort antibiotic

This paper shows that Pseudomonas aeruginosa produces novel glycolipids under phosphorus stress, which protect it from polymyxin B antibiotic.

Characterization of a glycolipid glycosyltransferase with broad substrate specificity from the marine bacterium Candidatus Pelagibacter sp. HTCC7211

This paper characterizes a glycolipid glycosyltransferase (GTcp) from Candidatus Pelagibacter sp. HTCC7211, showing its broad substrate specificity and role in glycoglycerolipid synthesis under phosphorus stress.

Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry

This study develops a selective DYRK2 inhibitor, C17, and identifies novel targets like 4E-BP1 and STIM1, revealing DYRK2's role in protein synthesis and calcium entry.

Quantifying phase separation property of chromatin associated proteins under physiological conditions using anti-1,6-hexanediol index

The paper quantifies the phase separation properties of chromatin-associated proteins using an anti-1,6-hexanediol index and shows functional correlations with chromatin organization.

Proteasome Regulation by Reversible Tyrosine Phosphorylation at the Membrane

This study identifies a novel mechanism where Src-mediated phosphorylation of Rpt2-Y439 regulates proteasome function at cellular membranes, impacting cancer therapy response.

A targetable epigenetic vulnerability in PI3K/AKT inhibitor resistant cancers

This study identifies an epigenetic vulnerability in PI3K/AKT inhibitor-resistant cancers, showing that targeting bromodomain or HDAC inhibitors can overcome resistance by modulating histone acetylation at growth factor/receptor gene loci.

Identification of Lipid Droplets in Gut Microbiota

The paper identifies lipid droplet-like structures in gut microbiota from mouse and human samples and establishes a method to study them.

YAP orchestrates heterotypic endothelial cell communication via HGF/c-MET signaling in liver tumorigenesis

This study shows YAP promotes liver tumor progression by altering the vascular niche, creating heterotypic communication between endothelial cell subtypes via HGF/c-MET signaling.

Protection of Rhesus Macaque from SARS-Coronavirus challenge by recombinant adenovirus vaccine

This study shows a recombinant adenovirus vaccine protects rhesus macaques from SARS-CoV challenge by inducing immune responses and reducing lung damage.

Enrichment of short mutant cell-free DNA fragments enhanced detection of pancreatic cancer

This study introduces SLHC-seq, a new targeted sequencing method that improves detection of pancreatic cancer by analyzing short mutant cfDNA fragments, enabling earlier diagnosis.

The Sequence of 1504 Mutants in the Model Rice Variety Kitaake Facilitates Rapid Functional Genomic Studies

The paper sequenced 1,504 mutant lines in the rice variety Kitaake and established a database to enable rapid functional genomic studies.