Cancer BiologybioRxiv
Silencing of oncogenic KRAS by mutant-selective small interfering RNA
B. Papke, S. H. Azam, A. Y. Feng…·C. V. Pecot
This study develops a mutant-selective siRNA, EFTX-D1, that targets KRAS mutations in codons 12 and 13, reducing mutant KRAS expression and impairing cancer cell proliferation.
DOI 10.1021/acsptsci.0c00165