Pancreatic islet cell stress induced by insulin-degrading enzyme deficiency promotes islet regeneration and protection from autoimmune diabetes
S. Zhu, E. Waeckel-Enee, A. Moser, M.-A. Bessard, K. Roger, J. Lipecka, A. Yilmaz, B. Bertocci, J. Diana, B. Saintpierre, I. C. Guerrera, S. Francesconi, F.-X. Mauvais, P. van Endert
This study shows that IDE deficiency in mice causes a low-level UPR, enhances beta cell proliferation, and protects against autoimmune diabetes through an anti-inflammatory pathway.
bioRxiv · Jul 19, 2023 · PreprintCell Biology