MicrobiologybioRxiv
Detection of cytosolic Shigella flexneri via a C-terminal triple-arginine motif of GBP1 inhibits actin-based motility
A. Piro, D. Hernandez, S. Luoma…·J. Coers
This paper shows human GBP1 uniquely captures cytosolic Gram-negative bacteria via a C-terminal triple-arginine motif, inhibiting their actin-based motility and cell-to-cell spread, while Shigella uses IpaH9.8 to resist GBP1 targeting.
DOI 10.1128/mbio.01979-17