Author

c. lesser

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

D. Hernandez· 2 shared J. Coers· 2 shared A. Piro· 1 shared A. Yirga· 1 shared C. Herrmann· 1 shared D. Needham· 1 shared E. Feeley· 1 shared E. Frickel· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

D. Hernandez

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2 papers

Recent·Most cited

GBP2 aggregates LPS and activates the caspase-4 inflammasome independent of the bacterial encapsulation factor GBP1

M. S. Dickinson, M. Kutsch, L. Sistemich, D. Hernandez, D. Needham, c. lesser, C. Herrmann, J. Coers

This paper shows GBP2 can trigger pyroptosis by aggregating free LPS and activating caspase-4, independent of GBP1's bacterial binding function.

bioRxiv · Oct 5, 2022Immunology

Detection of cytosolic Shigella flexneri via a C-terminal triple-arginine motif of GBP1 inhibits actin-based motility

A. Piro, D. Hernandez, S. Luoma, E. Feeley, R. Finethy, A. Yirga, E. Frickel, C. Lesser, J. Coers

This paper shows human GBP1 uniquely captures cytosolic Gram-negative bacteria via a C-terminal triple-arginine motif, inhibiting their actin-based motility and cell-to-cell spread, while Shigella uses IpaH9.8 to resist GBP1 targeting.

bioRxiv · Nov 1, 2017Microbiology