BiochemistrybioRxiv
Single position substitution of hairpin pyrrole-imidazole polyamides imparts distinct DNA-binding profiles across the human genome
P. B. Finn, D. Bhimsaria, A. Ali…·P. B. Dervan
The paper identifies genome-wide DNA-binding sites of hairpin pyrrole-imidazole polyamides using COSMIC-seq, showing that single-position substitutions alter binding profiles across the human genome.
DOI 10.1371/journal.pone.0243905