A. Eguchi

Phosphoproteomic investigation of targets of protein phosphatases in EGFR signaling

This study identifies phosphoproteomic targets of protein phosphatases in EGFR signaling using chemical inhibitors and mass spectrometry.

One-Tip enables comprehensive proteome coverage in minimal cells and single zygotes

One-Tip provides a proteomics method for high-depth protein identification from minimal cell samples and single zygotes with high throughput.

Subchronic Toxicity Assessment of Perfluoroalkyl Substances by Mixed Exposure of Nine Substances at Daily Intake Relevant Concentration

This study assesses the subchronic toxicity of a PFAS mixture in mice, finding liver morphological changes and alterations in metabolism and cancer-related gene expression.

TRF2 rescues telomere attrition and prolongs cell survival in Duchenne muscular dystrophy cardiomyocytes derived from human iPSCs

This study shows that upregulating TRF2 in DMD cardiomyocytes from iPSCs increases telomere length and improves cell survival.

Single position substitution of hairpin pyrrole-imidazole polyamides imparts distinct DNA-binding profiles across the human genome

The paper identifies genome-wide DNA-binding sites of hairpin pyrrole-imidazole polyamides using COSMIC-seq, showing that single-position substitutions alter binding profiles across the human genome.

The TAT Protein Transduction Domain as an Intra-articular Drug-Delivery Technology

This study evaluates the TAT peptide transduction domain as a drug delivery method for intra-articular therapies, showing its ability to deliver siRNA and induce genetic recombination in vivo.