Chemical-genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy
E.-I. Koh, P. O. Oluoch, N. Ruecker, M. K. Proulx, V. Soni, K. C. Murphy, K. G. Papavinasasundaram, C. J. Reames, C. Trujillo, A. Zaveri, M. D. Zimmerman, R. Aslebagh, R. E. Baker, S. A. Shaffer, K. M. Guinn, , C. M. Sassetti
This study maps chemical-genetic interactions in Mycobacterium tuberculosis to identify how carbon metabolism and cell wall structure affect drug efficacy, revealing environment-dependent and -independent interactions.
bioRxiv · Apr 8, 2021Microbiology