Author

D. Schnappinger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 9 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 7 Approach:experimental assay· 7 Organism:human· 5 Approach:genetic perturbation / CRISPR· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 2 Assay:whole-genome sequencing· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

S. Ehrt· 9 shared H. Su· 3 shared J. M. Rock· 3 shared K. Lin· 3 shared K. Y. Rhee· 3 shared T. Beites· 3 shared T. R. Ioerger· 3 shared Y. Liu· 3 shared

Activity by Year

2020-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

9 shared papersMicrobiology

S. Ehrt

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

A "suicide" BCG strain provides enhanced immunogenicity and robust protection against Mycobacterium tuberculosis in macaques

A. A. Smith, H. Su, J. Wallach, Y. Liu, P. Maiello, H. J. Borish, C. Winchell, A. W. Simonson, P. L. Lin, M. Rodgers, D. J. Filmore, J. Sakal, K. Lin, V. Vinette, D. Schnappinger, , J. L. Flynn

This study develops a 'suicide' BCG strain that is safely eliminated in immunocompromised hosts but induces stronger immune responses and better protection against Mtb in macaques.

bioRxiv · Nov 22, 2023 · PreprintImmunology

Development of an Engineered Mycobacterium tuberculosis Strain for a Safe and Effective Tuberculosis Human Challenge Model

X. Wang, H. Su, J. B. Wallach, J. C. Wagner, B. J. Braunecker, M. Gardner, K. M. Guinn, T. Klevorn, K. Lin, Y. J. Liu, Y. Liu, D. Mugahid, M. Rodgers, J. Sixsmith, S. Wakabayashi, , D. Schnappinger

This paper develops an engineered Mycobacterium tuberculosis strain with kill switches for a safe TB human challenge model, showing rapid clearance and low escape rates.

bioRxiv · Nov 19, 2023 · PreprintMicrobiology

Synthetic lethality of Mycobacterium tuberculosis NADH dehydrogenases is due to impaired NADH oxidation

Y. Xu, S. Ehrt, D. Schnappinger, T. Beites

The paper investigates synthetic lethality in Mycobacterium tuberculosis by showing that simultaneous inactivation of Ndh-1 and Ndh-2 NADH dehydrogenases leads to bacterial death due to impaired NADH oxidation.

bioRxiv · Apr 10, 2023 · PreprintMicrobiology

Cyclic AMP is a critical mediator of intrinsic drug resistance and fatty acid metabolism in M. tuberculosis

A. I. Wong, T. Beites, K. A. Planck, S. Li, N. C. Poulton, K. Rhee, D. Schnappinger, S. Ehrt, J. M. Rock

This study identifies cAMP as a key mediator of intrinsic drug resistance and fatty acid metabolism in M. tuberculosis by analyzing the role of the essential adenylate cyclase Rv3645.

bioRxiv · Jul 7, 2022Microbiology

Reliable detection of pyrazinamide antitubercular activity in vitro.

A. Gouzy, C. F. Healy, D. Schnappinger, S. Ehrt

This study demonstrates a reliable method to detect pyrazinamide activity in vitro using an acidic, lipid-rich medium that mimics Mtb infection conditions.

bioRxiv · May 22, 2022 · PreprintMicrobiology

A chemical-genetic map of the pathways controlling drug potency in Mycobacterium tuberculosis

S. Li, N. C. Poulton, J. S. Chang, Z. A. Azadian, M. A. Dejusus, N. Ruecker, M. D. Zimmerman, K. Eckartt, B. Bosch, C. A. Engelhart, D. Sullivan, M. Gengenbacher, V. A. Dartois, D. Schnappinger, J. M. Rock

This study uses a CRISPR interference platform to map drug resistance pathways in Mtb, identifying new intrinsic and acquired resistance mechanisms and potential drug targets.

bioRxiv · Nov 27, 2021 · PreprintMicrobiology

Multiple acyl-CoA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection

T. Beites, R. S. Jansen, R. Wang, A. Jinich, K. Y. Rhee, D. Schnappinger, S. Ehrt

This study identifies EtfDMtb as an essential dehydrogenase for fatty acid β-oxidation in Mtb, showing that disrupting it kills the bacterium in vitro and in mice.

bioRxiv · Apr 19, 2021Microbiology

Chemical-genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy

E.-I. Koh, P. O. Oluoch, N. Ruecker, M. K. Proulx, V. Soni, K. C. Murphy, K. G. Papavinasasundaram, C. J. Reames, C. Trujillo, A. Zaveri, M. D. Zimmerman, R. Aslebagh, R. E. Baker, S. A. Shaffer, K. M. Guinn, , C. M. Sassetti

This study maps chemical-genetic interactions in Mycobacterium tuberculosis to identify how carbon metabolism and cell wall structure affect drug efficacy, revealing environment-dependent and -independent interactions.

bioRxiv · Apr 8, 2021Microbiology

The Mycobacterium tuberculosis transposon sequencing database (MtbTnDB): a large-scale guide to genetic conditional essentiality

A. Jinich, A. Zaveri, M. A. DeJesus, E. Flores-Bautista, R. Almada-Monter, C. M. Smith, C. M. Sassetti, J. M. Rock, S. Ehrt, D. Schnappinger, T. R. Ioerger, K. Y. Rhee

The paper builds MtbTnDB, a database of Mtb TnSeq screens, enabling comparison of genetic essentiality across conditions and analysis of gene function.

bioRxiv · Mar 5, 2021 · PreprintMicrobiology

Genetic models of latent tuberculosis in mice reveal differential control by adaptive immunity

H. Su, K. Lin, D. Tiwari, C. Healy, C. Trujillo, Y. Liu, T. R. Ioerger, D. Schnappinger, S. Ehrt

This study develops genetic mouse models of latent tuberculosis, revealing that adaptive immunity differentially controls relapse depending on the model used.

bioRxiv · Feb 8, 2021Microbiology

Re-discovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis

H. Wang, M. Xu, C. A. Engelhart, X. Zhang, B. Yan, M. Pan, Y. Xu, S. Fan, R. Liu, L. Xu, L. Hua, D. Schnappinger, S. Chen

The paper identifies PF-3845 as a novel inhibitor of Mycobacterium tuberculosis PheRS, showing selectivity over human PheRS and potential as an antibiotic lead.

bioRxiv · Oct 27, 2020Biochemistry